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Comment
. 2019 Apr 4;24(4):503-505.
doi: 10.1016/j.stem.2019.03.016.

Beta Living through Alpha Cells

Sophie Patzek  1 , Julie B Sneddon  2
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Free article
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Beta Living through Alpha Cells

Sophie Patzek et al. Cell Stem Cell. .
Free article

Abstract

Recently in Nature, Furuyama et al. (2019) provide evidence for lineage plasticity in the human endocrine pancreas, demonstrating that α cells derived from adult human pancreatic islets can be reprogrammed to become glucose-responsive, insulin-secreting β-like cells that are capable of reversing diabetes in mouse models.

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  • Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.
    Furuyama K, Chera S, van Gurp L, Oropeza D, Ghila L, Damond N, Vethe H, Paulo JA, Joosten AM, Berney T, Bosco D, Dorrell C, Grompe M, Ræder H, Roep BO, Thorel F, Herrera PL. Furuyama K, et al. Nature. 2019 Mar;567(7746):43-48. doi: 10.1038/s41586-019-0942-8. Epub 2019 Feb 13. Nature. 2019. PMID: 30760930 Free PMC article.

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