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. 2019 Apr 4;24(4):511-512.
doi: 10.1016/j.stem.2019.03.001.

Measure Twice, Cut Once: Therapeutic Editing of HSPCs Requires Precise Planning

Rachel E Rau  1 , Margaret A Goodell  2
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Measure Twice, Cut Once: Therapeutic Editing of HSPCs Requires Precise Planning

Rachel E Rau et al. Cell Stem Cell. .
Free article

Abstract

Hematologic diseases may be among the first clinical targets for therapeutic gene editing. In this issue of Cell Stem Cell, Schiroli et al. (2019) report a thorough, unbiased investigation of the impact of gene editing on hematopoietic stem and progenitor function and offer a clear path forward for editing in multiple tissues and conditions.

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