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Comment
. 2019 Apr 4;177(2):228-230.
doi: 10.1016/j.cell.2019.03.027.

Mapping Extracellular RNA Sheds Lights on Distinct Carriers

Cecilia Lässer  1
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Free article
Comment

Mapping Extracellular RNA Sheds Lights on Distinct Carriers

Cecilia Lässer. Cell. .
Free article

Abstract

Circulating extracellular RNA can participate in cell-to-cell communication and can be used as a marker of disease. Currently, biological and technical variability prevents the field from reaching its full potential. In this issue of Cell and the April 24 issue of Cell Systems, three studies by the Extracellular RNA Communication Consortium (ERCC) (Murillo et al., 2019; Srinivasan et al., 2019; Rozowsky et al., 2019) address several aspects contributing to this variability and provide knowledge and platforms for empowering future studies.

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  • Small RNA Sequencing across Diverse Biofluids Identifies Optimal Methods for exRNA Isolation.
    Srinivasan S, Yeri A, Cheah PS, Chung A, Danielson K, De Hoff P, Filant J, Laurent CD, Laurent LD, Magee R, Moeller C, Murthy VL, Nejad P, Paul A, Rigoutsos I, Rodosthenous R, Shah RV, Simonson B, To C, Wong D, Yan IK, Zhang X, Balaj L, Breakefield XO, Daaboul G, Gandhi R, Lapidus J, Londin E, Patel T, Raffai RL, Sood AK, Alexander RP, Das S, Laurent LC. Srinivasan S, et al. Cell. 2019 Apr 4;177(2):446-462.e16. doi: 10.1016/j.cell.2019.03.024. Cell. 2019. PMID: 30951671 Free PMC article.
  • exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids.
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  • exceRpt: A Comprehensive Analytic Platform for Extracellular RNA Profiling.
    Rozowsky J, Kitchen RR, Park JJ, Galeev TR, Diao J, Warrell J, Thistlethwaite W, Subramanian SL, Milosavljevic A, Gerstein M. Rozowsky J, et al. Cell Syst. 2019 Apr 24;8(4):352-357.e3. doi: 10.1016/j.cels.2019.03.004. Epub 2019 Apr 4. Cell Syst. 2019. PMID: 30956140 Free PMC article.

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