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Comment
. 2019 Jun 15;25(12):3476-3478.
doi: 10.1158/1078-0432.CCR-19-0853. Epub 2019 Apr 5.

A Novel Autocrine CXCL14/ACKR2 Axis: The Achilles' Heel of Cancer Metastasis?

Qian Zhang #  1 , Nianxin Zhou #  1 , Wei Wang  1   2 , Shengtao Zhou  3
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A Novel Autocrine CXCL14/ACKR2 Axis: The Achilles' Heel of Cancer Metastasis?

Qian Zhang et al. Clin Cancer Res. .

Abstract

Cancer-associated fibroblasts (CAF) are essential for cancer hallmarks. While CAFs are molecularly heterogeneous, a CXCL14-expressing subset has been a critical player in the cancer context. In breast cancer, an autocrine fibroblast CXCL14/ACKR2 axis mediates epithelial-to-mesenchymal transition and endows metastatic traits, which offers novel therapeutic potential in the clinical setting.See related article by Sjöberg et al., p. 3702.

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