Glyphosate Excretion is Associated With Steatohepatitis and Advanced Liver Fibrosis in Patients With Fatty Liver Disease

Paul J Mills¹, Cyrielle Caussy², Rohit Loomba³

Affiliations

¹ Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, California. Electronic address: pmills@ucsd.edu.
² NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, California; Université Lyon 1, Hospices Civils de Lyon, Lyon, France.
³ NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, California; Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California.

PMID: 30954713
PMCID: PMC6776714
DOI: 10.1016/j.cgh.2019.03.045

Glyphosate Excretion is Associated With Steatohepatitis and Advanced Liver Fibrosis in Patients With Fatty Liver Disease

Paul J Mills et al. Clin Gastroenterol Hepatol. 2020 Mar.

. 2020 Mar;18(3):741-743.

doi: 10.1016/j.cgh.2019.03.045. Epub 2019 Apr 4.

Authors

Paul J Mills¹, Cyrielle Caussy², Rohit Loomba³

Affiliations

¹ Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, California. Electronic address: pmills@ucsd.edu.
² NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, California; Université Lyon 1, Hospices Civils de Lyon, Lyon, France.
³ NAFLD Research Center, Department of Medicine, University of California, San Diego, La Jolla, California; Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California.

PMID: 30954713
PMCID: PMC6776714
DOI: 10.1016/j.cgh.2019.03.045

Abstract

Nonalcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease in developed countries.¹ Patients with nonalcoholic steatohepatitis (NASH) are considered to be at a higher risk of fibrosis progression and development to cirrhosis and hepatocellular carcinoma.

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Conflict of interest statement

COIs. The authors report no conflicts of interest.

References

1. Loomba R, Sanyal AJ. The global NAFLD epidemic. Nat Rev Gastroenterol Hepatol. 2013;10(11):686–90. - PubMed
1. Yang JS, Park Y. Insecticide Exposure and Development of Nonalcoholic Fatty Liver Disease. J Agric Food Chem. 2018;66(39):10132–8. Epub 2018/09/08. - PubMed
1. Myers JP, Antoniou MN, Blumberg B, et al. Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement. Environ Health. 2016;15:19. Epub 2016/02/18. - PMC - PubMed
1. Mesnage R, Renney G, Seralini GE, et al. Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide. Sci Rep. 2017;7:39328. Epub 2017/01/10. - PMC - PubMed
1. Mesnage R, Arno M, Costanzo M, et al. Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure. Environ Health. 2015;14:70. - PMC - PubMed

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Glyphosate Excretion is Associated With Steatohepatitis and Advanced Liver Fibrosis in Patients With Fatty Liver Disease

Affiliations

Glyphosate Excretion is Associated With Steatohepatitis and Advanced Liver Fibrosis in Patients With Fatty Liver Disease

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Conflict of interest statement

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