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. 2019 Mar;43(1):54-58.
doi: 10.1007/s12639-018-1055-2. Epub 2018 Nov 20.

Level of circulating steroid hormones in malaria and cutaneous leishmaniasis: a case control study

Farideh Esfandiari  1 , Bahador Sarkari  1   2 , Habibollah Turki  3 , Nasir Arefkhah  1 , Najme Shakouri  1
Affiliations

Level of circulating steroid hormones in malaria and cutaneous leishmaniasis: a case control study

Farideh Esfandiari et al. J Parasit Dis. 2019 Mar.

Abstract

Epidemiological and clinical studies have shown a great difference in the severity and prevalence of infectious diseases in men and women and various studies have shown that the key immunological factors are affected by sex-associated hormones. Considering the role of sex hormones in various infections, the current study aimed to determine the level of sex hormones in patients with cutaneous leishmaniasis (CL) and malaria and compare it with those of healthy controls. The survey was designed as a case-control study. Peripheral blood was collected from thirty male malaria patients, sixty patients (equal number of both sexes) with cutaneous leishmaniasis and ninety healthy subjects. Disease confirmations were done through microscopic examination of either peripheral blood smears, in case of malaria, or Giemsa-stained lesion imprint slides for CL. The level of testosterone, progesterone and estrogen were measured in malaria and CL patients along with healthy subjects, using an ELISA commercial kit. Age of participants was 18-35 years (mean 25.39 ± 4.70) for CL patients and 14-41 years (mean 27.63 ± 9.09) for malaria patients. Differences between the age of patients and the healthy subjects were insignificant. The level of testosterone in malaria patients (1.44 ± 0.12 ng/mL) was lower than control group (1.46 ± 0.06, ng/mL) but the differences were not statistically significant (p > .05). The concentration of testosterone in CL patients (1.49 ± 0.03 ng/mL) was higher than those of control group (1.46 ± 0.06 ng/mL), and the difference was statistically significant (p = 0.05). Although the concentration of estrogen and progesterone in CL patients were lower than controls, still the differences were not statistically significant (p > 0.05). Findings of the current study demonstrated a significant difference in the serum level of testosterone in CL patients in comparison with the healthy subjects whereas such difference was not seen in malaria patients.

Keywords: Cutaneous leishmaniasis; Malaria; Steroid hormones.

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