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Review
. 2019 Apr 8;68(Suppl 3):S206-S212.
doi: 10.1093/cid/ciz004.

Current Treatment Options for Acute Skin and Skin-structure Infections

Yoav Golan  1
Affiliations
Review

Current Treatment Options for Acute Skin and Skin-structure Infections

Yoav Golan. Clin Infect Dis. .

Abstract

Acute bacterial skin and skin-structure infections (ABSSSIs) are a common reason for seeking care at acute healthcare facilities, including emergency departments. Staphylococcus aureus is the most common organism associated with these infections, and the emergence of community-associated methicillin-resistant Staphylococcus aureus (MRSA) has represented a considerable challenge in their treatment. To address this need, a number of new antibiotics have been developed for the treatment of ABSSSIs in the past several years. Most of these agents focus primarily on gram-positive organisms, particularly MRSA; however, there has not been an oral agent that can reliably treat MRSA, as well as relevant gram-negative pathogens. Acute skin infections that involve mixed gram-positive and gram-negative pathogens must also be considered as they can be associated with discordant antimicrobial therapy. Here, I review ABSSSI treatment guidelines in the hospital setting and discuss current and future antibiotic options for treatment of this commonly encountered infection.

Keywords: abscess; antibiotic resistance; skin infection; therapy.

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References

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