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Case Reports
. 2019 Nov 8;19(4):400-403.
doi: 10.17305/bjbms.2019.4182.

Clear cell urothelial carcinoma of the urinary bladder - a rare pathological entity. A case report and a systematic review of the literature

Ioana Mihai  1 , Sorina Taban, Alin Cumpanas, Emilian Gh Olteanu, Mihaela Iacob, Alis Dema
Affiliations
Case Reports

Clear cell urothelial carcinoma of the urinary bladder - a rare pathological entity. A case report and a systematic review of the literature

Ioana Mihai et al. Bosn J Basic Med Sci. .

Abstract

The most common histological type of urinary bladder cancer is urothelial carcinoma (UC). In contrast, the clear cell variant of urothelial carcinoma (CCUC) is quite a rare neoplasm. In this study, we report a case of an 81-year-old male, presenting with gross hematuria and acute urinary retention, which was subsequently diagnosed with CCUC at our pathology department. Furthermore, we provide a short systematic review of the literature (PubMed, Scopus, and Science Citation Index) for this rare histopathological entity and a brief discussion about its morphological and immunohistochemical (IHC) characteristics.

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Figures

FIGURE 1
FIGURE 1
Gross aspect of the cystoprostatectomy specimen. Invasion through the detrusor muscle into the perivesical adipose tissue.
FIGURE 2
FIGURE 2
(A) Sheets of clear cells invading the muscularis propria, hematoxylin and eosin (HE), ×200. (B) Periodic acid-Schiff (PAS) staining demonstrating glycogen content of the tumor cells, ×200. (C-F) Positive reaction for GATA3, p63, CD44, and cytokeratin 5, ×400.
See this image and copyright information in PMC

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