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Review
. 2019 Jan 31;9(1):180212.
doi: 10.1098/rsob.180212.

Emerging microRNA biomarkers for colorectal cancer diagnosis and prognosis

Bing Chen  1   2 , Zijing Xia  1   3 , Ya-Nan Deng  1 , Yanfang Yang  1 , Peng Zhang  4 , Hongxia Zhu  5 , Ningzhi Xu  1   5 , Shufang Liang  1
Affiliations
Review

Emerging microRNA biomarkers for colorectal cancer diagnosis and prognosis

Bing Chen et al. Open Biol. .

Abstract

MicroRNAs (miRNAs) are one abundant class of small, endogenous non-coding RNAs, which regulate various biological processes by inhibiting expression of target genes. miRNAs have important functional roles in carcinogenesis and development of colorectal cancer (CRC), and emerging evidence has indicated the feasibility of miRNAs as robust cancer biomarkers. This review summarizes the progress in miRNA-related research, including study of its oncogene or tumour-suppressor roles and the advantages of miRNA biomarkers for CRC diagnosis, treatment and recurrence prediction. Along with analytical technique improvements in miRNA research, use of the emerging extracellular miRNAs is feasible for CRC diagnosis and prognosis.

Keywords: biomarkers; colorectal cancer; diagnosis and prognosis; microRNAs.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1.
Figure 1.
Promising clinical value of miRNAs in diagnosis, treatment and prognosis of CRC. Analysing and quantifying the levels of miRNAs extracted from clinical samples such as tissue, plasma, serum and faeces can help to diagnose and make decisions for CRC treatment and prognosis.
See this image and copyright information in PMC

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