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Review
. 2019 Apr 5;8(4):91.
doi: 10.3390/antiox8040091.

Juglone in Oxidative Stress and Cell Signaling

Taseer Ahmad  1 , Yuichiro J Suzuki  2
Affiliations
Review

Juglone in Oxidative Stress and Cell Signaling

Taseer Ahmad et al. Antioxidants (Basel). .

Abstract

Juglone (5-hydroxyl-1,4-naphthoquinone) is a phenolic compound found in walnuts. Because of the antioxidant capacities of phenolic compounds, juglone may serve to combat oxidative stress, thereby protecting against the development of various diseases and aging processes. However, being a quinone molecule, juglone could also act as a redox cycling agent and produce reactive oxygen species. Such prooxidant properties of juglone may confer health effects, such as by killing cancer cells. Further, recent studies revealed that juglone influences cell signaling. Notably, juglone is an inhibitor of Pin1 (peptidyl-prolyl cis/trans isomerase) that could regulate phosphorylation of Tau, implicating potential effects of juglone in Alzheimer's disease. Juglone also activates mitogen-activated protein kinases that could promote cell survival, thereby protecting against conditions such as cardiac injury. This review describes recent advances in the understanding of the effects and roles of juglone in oxidative stress and cell signaling.

Keywords: Pin1; antioxidants; juglone; naphthoquinone; redox; signal transduction; walnuts.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structure of juglone.
Figure 2
Figure 2
Schematic diagram describing the antioxidant properties of phenolic compounds including juglone.
Figure 3
Figure 3
The schematic diagram showing the oxidant potential of juglone and its therapeutic applications.
See this image and copyright information in PMC

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