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. 2019 Apr 5;17(4):214.
doi: 10.3390/md17040214.

New Furanocembranoids from Briareum violaceum

Pin-Chang Huang  1   2 , Wen-Sou Lin  3   4 , Bo-Rong Peng  5 , Yu-Chia Chang  6 , Lee-Shing Fang  7   8 , Guo-Qiang Li  9   10 , Tsong-Long Hwang  11   12   13   14 , Zhi-Hong Wen  15 , Ping-Jyun Sung  16   17   18   19   20   21
Affiliations

New Furanocembranoids from Briareum violaceum

Pin-Chang Huang et al. Mar Drugs. .

Abstract

Three new furanocembranoids-briaviodiol F (1) and briaviotriols A (2) and B (3)-along with a known analogue, briaviodiol A (4), were obtained from a cultured-type octocoral Briareum violaceum. The structures of cembranoids 1⁻3 were elucidated by using spectroscopic methods. In vitro study demonstrated that compounds 2 and 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW 264.7, a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides.

Keywords: Briareum violaceum; anti-inflammatory; briaviodiol; briaviotriol; iNOS.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Structures of briaviodiol F (1), briaviotriols A (2) and B (3), and briaviodiol A (4), and a picture of the octocoral B. violaceum.
Figure 2
Figure 2
Computer-depicted model drawing of 1 and calculated distances (unit = Å) between protons with main NOESY correlations.
Figure 3
Figure 3
Computer-depicted model drawing of 2 and calculated distances (unit = Å) between protons with main NOESY correlations.
Figure 4
Figure 4
Computer-depicted model drawing of 3 and calculated distances (unit = Å) between protons with main NOESY correlations.
See this image and copyright information in PMC

References

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