Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jan 6;11(1):77.
doi: 10.3390/polym11010077.

Chemical Synthesis and Characterization of Poly(poly(ethylene glycol) methacrylate)-Grafted CdTe Nanocrystals via RAFT Polymerization for Covalent Immobilization of Adenosine

Trinh Duy Nguyen  1   2 , Hieu Vu-Quang  3 , Thanh Sang Vo  4 , Duy Chinh Nguyen  5   6 , Dai-Viet N Vo  7 , Dai Hai Nguyen  8   9 , Kwon Taek Lim  10 , Dai Lam Tran  11   12 , Long Giang Bach  13   14
Affiliations

Chemical Synthesis and Characterization of Poly(poly(ethylene glycol) methacrylate)-Grafted CdTe Nanocrystals via RAFT Polymerization for Covalent Immobilization of Adenosine

Trinh Duy Nguyen et al. Polymers (Basel). .

Abstract

This paper describes the functionalization of poly(poly(ethylene glycol) methacrylate) (PPEGMA)-grafted CdTe (PPEGMA-g-CdTe) quantum dots (QDs) via surface-initiated reversible addition⁻fragmentation chain transfer (SI-RAFT) polymerization for immobilization of adenosine. Initially, the hydroxyl-coated CdTe QDs, synthesized using 2-mercaptoethanol (ME) as a capping agent, were coupled with a RAFT agent, S-benzyl S'-trimethoxysilylpropyltrithiocarbonate (BTPT), through a condensation reaction. Then, 2,2'-azobisisobutyronitrile (AIBN) was used to successfully initiate in situ RAFT polymerization to generate PPEGMA-g-CdTe nanocomposites. Adenosine-above-PPEGMA-grafted CdTe (Ado-i-PPEGMA-g-CdTe) hybrids were formed by the polymer shell, which had successfully undergone bioconjugation and postfunctionalization by adenosine (as a nucleoside). Fourier transform infrared (FT-IR) spectrophotometry, energy-dispersive X-ray (EDX) spectroscopy, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy results indicated that a robust covalent bond was created between the organic PPEGMA part, cadmium telluride (CdTe) QDs, and the adenosine conjugate. The optical properties of the PPEGMA-g-CdTe and Ado-i-PPEGMA-g-CdTe hybrids were investigated by photoluminescence (PL) spectroscopy, and the results suggest that they have a great potential for application as optimal materials in biomedicine.

Keywords: CdTe quantum dots; SI-RAFT; adenosine; covalent immobilization; poly(poly(ethylene glycol methacrylate).

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
Route for the synthesis of poly(poly(ethylene glycol) methacrylate) (PPEGMA)-coated CdTe quantum dots (QDs) via reversible addition–fragmentation chain transfer (RAFT) polymerization and subsequent conjugation of adenosine.
Figure 1
Figure 1
Fourier transform infrared (FT-IR) spectra of (A) CdTe-OH, (B) CdTe- S-benzyl S′-trimethoxysilylpropyltrithiocarbonate (BTPT), and (C) PPEGMA-grafted CdTe (PPEGMA-g-CdTe).
Figure 2
Figure 2
Energy-dispersive X-ray (EDX) spectra of (A) CdTe-OH and (B) CdTe-BTPT. X-ray photoelectron spectroscopy (XPS) spectra of wide-scan of (C) CdTe-OH, and (D) CdTe-BTPT.
Figure 3
Figure 3
Thermogravimetric analysis (TGA) scans of (A) CdTe-OH, (B) CdTe-BTPT, and (C) PPEGMA-g-CdTe.
Figure 4
Figure 4
FT-IR spectra of (A) DSC-f-PPEGMA-g-CdTe, (B) Adenosine-above-PPEGMA-grafted CdTe (Ado-i-PPEGMA-g-CdTe) hybrids.
Figure 5
Figure 5
Wide scans and N1s core-level spectra of (A,B) PPEGMA-g-CdTe, (C,D) DSC-f-PPEGMA-g-CdTe, and (E,F) Ado-i-PPEGMA-g-CdTe nanohybrids, respectively.
Figure 6
Figure 6
Photoluminescence (PL) spectra (excited at 380 nm) of (A) CdTe-OH QDs, (B) PPEGMA-g-CdTe, and (C) Ado-i-PPEGMA-g-CdTe nanohybrids.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Brichkin S.B., Razumov V.F. Colloidal Quantum Dots: Synthesis, Properties and Applications. Russ. Chem. Rev. 2016;85:1297–1312. doi: 10.1070/RCR4656. - DOI
    1. Rakovich A., Savateeva D., Rakovich T., Donegan J.F., Rakovich Y.P., Kelly V., Lesnyak V., Eychmüller A. CdTe Quantum Dot/Dye Hybrid System as Photosensitizer for Photodynamic Therapy. Nanoscale Res. Lett. 2010;5:753–760. doi: 10.1007/s11671-010-9553-x. - DOI - PMC - PubMed
    1. Rizvi S.B., Ghaderi S., Keshtgar M., Seifalian A.M. Semiconductor Quantum Dots as Fluorescent Probes for in Vitro and in Vivo Bio-Molecular and Cellular Imaging. Nanoscale Rev. 2010;1:5161. - PMC - PubMed
    1. Bilan R., Nabiev I., Sukhanova A. Quantum Dot-Based Nanotools for Bioimaging, Diagnostics, and Drug Delivery. ChemBioChem. 2016;17:2103–2114. doi: 10.1002/cbic.201600357. - DOI - PubMed
    1. Zhao M.X., Zeng E.Z. Application of Functional Quantum Dot Nanoparticles as Fluorescence Probes in Cell Labeling and Tumor Diagnostic Imaging. Nanoscale Res. Lett. 2015;10:171. doi: 10.1186/s11671-015-0873-8. - DOI - PMC - PubMed

LinkOut - more resources