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Review
. 2018 Oct 12;10(10):1133.
doi: 10.3390/polym10101133.

Hyaluronic Acid-Based Nanomaterials for Cancer Therapy

Jin Hong Kim  1 , Myeong Ju Moon  2 , Dong Yi Kim  3 , Suk Hee Heo  4 , Yong Yeon Jeong  5
Affiliations
Review

Hyaluronic Acid-Based Nanomaterials for Cancer Therapy

Jin Hong Kim et al. Polymers (Basel). .

Abstract

Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan and a major component of the extracellular matrix. HA is overexpressed by numerous tumor cells, especially tumor-initiating cells. HA-based nanomaterials play in importance role in drug delivery systems. HA is used in various types of nanomaterials including micelle, polymersome, hydrogel, and inorganic nanoparticle formulations. Many experiments show that HA-based nanomaterials can serve as a platform for targeted chemotherapy, gene therapy, immunotherapy, and combination therapy with good potential for future biomedical applications in cancer treatment.

Keywords: cancer; chemotherapy; combination cancer therapy; gene deliver; hyaluronic acid (HA); immunotherapy; nanoparticles (NPs); target therapy.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Formulations of hyaluronic acid (HA)-based nanomaterials.
Figure 2
Figure 2
Chemical modification of hyaluronic acid for binding hydrophobic molecules to form micelles.
Figure 3
Figure 3
Chemical modification of hyaluronic acid to form hydrogels.
Figure 4
Figure 4
Illustration of redox-sensitive HA-ss-DOCA micelles (Modified from Reference [48]).
See this image and copyright information in PMC

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