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. 2020 Feb:33:45-51.
doi: 10.1016/j.prrv.2019.01.001. Epub 2019 Jan 20.

Exogenous lipoid pneumonia in children: A systematic review

Diana Marangu  1 , Diane Gray  2 , Aneesa Vanker  2 , Marco Zampoli  2
Affiliations

Exogenous lipoid pneumonia in children: A systematic review

Diana Marangu et al. Paediatr Respir Rev. 2020 Feb.

Abstract

Objectives: To describe the clinical-radiological-pathological characteristics and treatment outcomes of children with suspected exogenous lipoid pneumonia (ELP).

Design: Systematic review. We searched electronic databases and reference lists published between 1967 and 2018, restricted to non-accidental cases.

Results: Forty-four studies including 489 participants aged 1 day to 17 years from 13 countries were included. Cultural, medical, and behavioural rationale for oil-use was described. The clinical-radiological presentation varied widely. Diagnostic certainty was deemed highest if ELP was confirmed on bronchoalveolar lavage/frozen section lung biopsy with documented extracellular lipid on cytological staining and/or fat analysis. Non-tuberculous mycobacteria infection was identified in six studies: Mycobacterium fortuitum/chelonei, Mycobacterium smegmatis and Mycobacterium abscessus. Treatment comprised supportive therapy, corticosteroids, stopping oil, therapeutic lung-lavage and surgical resection. Outcomes were reported inconsistently.

Conclusion: Paediatric ELP resulting from cultural and medical practices continues to be described globally. Preventive interventions, standardized reporting, and treatment efficacy studies for cases not averted, are lacking. Protocol registration: PROSPERO CRD42017068313.

Keywords: Children’s interstitial lung disease (chILD); Global Health; Oil.

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Figures

Fig. 1
Fig. 1
PRISMA flow chart.
Fig. 2
Fig. 2
Global map depicting the number of studies published on non-accidental paediatric exogenous lipoid pneumonia in the English literature.
Fig. 3
Fig. 3
Examples of radio-pathological characteristics of paediatric exogenous lipoid pneumonia from an African Case Series .
See this image and copyright information in PMC

References

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