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Comment
. 2019 May 6;216(5):1012-1013.
doi: 10.1084/jem.20190378. Epub 2019 Apr 8.

When pregnancy tames the wolf

Timothy B Niewold  1 , Shilpi Mehta-Lee  2
Affiliations
Comment

When pregnancy tames the wolf

Timothy B Niewold et al. J Exp Med. .

Abstract

A state of relative immunosuppression exists in normal pregnancy. In this issue of JEM, Hong et al. (https://doi.org/10.1084/jem.20190185) perform blood immunomonitoring in pregnancy, in both healthy women and women with lupus, and observe early and sustained transcriptional modulation of lupus-related pathways in both groups. When signatures of inflammation did not normalize in lupus, risk of pregnancy complications was increased.

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Figures

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Insights from Timothy B. Niewold and Shilpi Mehta-Lee.
See this image and copyright information in PMC

Comment on

  • Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy.
    Hong S, Banchereau R, Maslow BL, Guerra MM, Cardenas J, Baisch J, Branch DW, Porter TF, Sawitzke A, Laskin CA, Buyon JP, Merrill J, Sammaritano LR, Petri M, Gatewood E, Cepika AM, Ohouo M, Obermoser G, Anguiano E, Kim TW, Nulsen J, Nehar-Belaid D, Blankenship D, Turner J, Banchereau J, Salmon JE, Pascual V. Hong S, et al. J Exp Med. 2019 May 6;216(5):1154-1169. doi: 10.1084/jem.20190185. Epub 2019 Apr 8. J Exp Med. 2019. PMID: 30962246 Free PMC article.

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