Off-target effects and the solution

Jintao Tang^{1

2

3}, Letian Chen^{1

2

3}, Yao-Guang Liu^{4

5

6}

Affiliations

¹ State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, China.
² Key Laboratory of Plant Functional Genomics and Biotechnology of Guangdong Provincial Higher Education Institutions, South China Agricultural University, Guangzhou, China.
³ College of Life Sciences, South China Agricultural University, Guangzhou, China.
⁴ State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, China. ygliu@scau.edu.cn.
⁵ Key Laboratory of Plant Functional Genomics and Biotechnology of Guangdong Provincial Higher Education Institutions, South China Agricultural University, Guangzhou, China. ygliu@scau.edu.cn.
⁶ College of Life Sciences, South China Agricultural University, Guangzhou, China. ygliu@scau.edu.cn.

Comment

Jintao Tang et al. Nat Plants. 2019 Apr.

. 2019 Apr;5(4):341-342.

doi: 10.1038/s41477-019-0406-z.

Jintao Tang^{1

2

3}, Letian Chen^{1

2

3}, Yao-Guang Liu^{4

5

6}

¹ State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, China.
² Key Laboratory of Plant Functional Genomics and Biotechnology of Guangdong Provincial Higher Education Institutions, South China Agricultural University, Guangzhou, China.
³ College of Life Sciences, South China Agricultural University, Guangzhou, China.
⁴ State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou, China. ygliu@scau.edu.cn.
⁵ Key Laboratory of Plant Functional Genomics and Biotechnology of Guangdong Provincial Higher Education Institutions, South China Agricultural University, Guangzhou, China. ygliu@scau.edu.cn.
⁶ College of Life Sciences, South China Agricultural University, Guangzhou, China. ygliu@scau.edu.cn.

No abstract available

Comment on

Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.
Zuo E, Sun Y, Wei W, Yuan T, Ying W, Sun H, Yuan L, Steinmetz LM, Li Y, Yang H. Zuo E, et al. Science. 2019 Apr 19;364(6437):289-292. doi: 10.1126/science.aav9973. Epub 2019 Feb 28. Science. 2019. PMID: 30819928 Free PMC article.
Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice.
Jin S, Zong Y, Gao Q, Zhu Z, Wang Y, Qin P, Liang C, Wang D, Qiu JL, Zhang F, Gao C. Jin S, et al. Science. 2019 Apr 19;364(6437):292-295. doi: 10.1126/science.aaw7166. Epub 2019 Feb 28. Science. 2019. PMID: 30819931