Cellular senescence causes ageing

doi:10.1038/s41580-019-0128-0

Comment

. 2019 Jul;20(7):388.

doi: 10.1038/s41580-019-0128-0.

Cellular senescence causes ageing

Jesús Gil¹

Affiliations

PMID: 30962572
DOI: 10.1038/s41580-019-0128-0

Free article

Comment

Cellular senescence causes ageing

Jesús Gil. Nat Rev Mol Cell Biol. 2019 Jul.

Free article

. 2019 Jul;20(7):388.

doi: 10.1038/s41580-019-0128-0.

Author

Jesús Gil¹

Affiliation

¹ MRC London Institute of Medical Sciences (LMS) and Institute of Clinical Sciences (ICS), Imperial College London, London, UK. jesus.gil@imperial.ac.uk.

PMID: 30962572
DOI: 10.1038/s41580-019-0128-0

No abstract available

PubMed Disclaimer

Comment on

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders.
Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. Baker DJ, et al. Nature. 2011 Nov 2;479(7372):232-6. doi: 10.1038/nature10600. Nature. 2011. PMID: 22048312 Free PMC article.

Cited by

H3K4 Methylation in Aging and Metabolism.
Hsu CL, Lo YC, Kao CF. Hsu CL, et al. Epigenomes. 2021 Jun 18;5(2):14. doi: 10.3390/epigenomes5020014. Epigenomes. 2021. PMID: 34968301 Free PMC article. Review.
Proteomic Insights into Senescence of Testicular Peritubular Cells from a Nonhuman Primate Model.
Stöckl JB, Schmid N, Flenkenthaler F, Drummer C, Behr R, Mayerhofer A, Arnold GJ, Fröhlich T. Stöckl JB, et al. Cells. 2020 Nov 17;9(11):2498. doi: 10.3390/cells9112498. Cells. 2020. PMID: 33213088 Free PMC article.
Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population.
DePianto DJ, Heiden JAV, Morshead KB, Sun KH, Modrusan Z, Teng G, Wolters PJ, Arron JR. DePianto DJ, et al. JCI Insight. 2021 Apr 22;6(8):e143626. doi: 10.1172/jci.insight.143626. JCI Insight. 2021. PMID: 33705361 Free PMC article.
Iron retardation in lysosomes protects senescent cells from ferroptosis.
Feng Y, Wei H, Lyu M, Yu Z, Chen J, Lyu X, Zhuang F. Feng Y, et al. Aging (Albany NY). 2024 Apr 26;16(9):7683-7703. doi: 10.18632/aging.205777. Epub 2024 Apr 26. Aging (Albany NY). 2024. PMID: 38683121 Free PMC article.
Cell senescence in neuropathology: A focus on neurodegeneration and tumours.
Carreno G, Guiho R, Martinez-Barbera JP. Carreno G, et al. Neuropathol Appl Neurobiol. 2021 Apr;47(3):359-378. doi: 10.1111/nan.12689. Epub 2021 Feb 1. Neuropathol Appl Neurobiol. 2021. PMID: 33378554 Free PMC article. Review.

See all "Cited by" articles

References

Original articles

1. Baker, D. J. et al. Clearance of p16^Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479, 232–236 (2011) - DOI
1. Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585–621 (1961) - DOI
1. Narita, M. & Lowe, S. W. Senescence comes of age. Nat. Med. 11, 920–922 (2005) - DOI
1. Serrano, M. et al. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16^INK4a. Cell 88, 593–602 (1997) - DOI

Publication types

Actions

MeSH terms

Actions
Actions
Actions

Grants and funding

MC_U120085810/MRC_/Medical Research Council/United Kingdom

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
- Spiral, Imperial College Digital Repository

[1] Baker, D. J. et al. Clearance of p16^Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479, 232–236 (2011) - DOI

[2] Baker, D. J. et al. Clearance of p16^Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479, 232–236 (2011) - DOI

[3] Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585–621 (1961) - DOI

[4] Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585–621 (1961) - DOI

[5] Narita, M. & Lowe, S. W. Senescence comes of age. Nat. Med. 11, 920–922 (2005) - DOI

[6] Narita, M. & Lowe, S. W. Senescence comes of age. Nat. Med. 11, 920–922 (2005) - DOI

[7] Serrano, M. et al. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16^INK4a. Cell 88, 593–602 (1997) - DOI

[8] Serrano, M. et al. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16^INK4a. Cell 88, 593–602 (1997) - DOI

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Cellular senescence causes ageing

Affiliation

Cellular senescence causes ageing

Author

Affiliation

Comment on

Similar articles

Cited by

References

Original articles

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources