Progress in the Chemistry of Tetrahydroquinolines
- PMID: 30963764
- DOI: 10.1021/acs.chemrev.8b00567
Progress in the Chemistry of Tetrahydroquinolines
Abstract
Tetrahydroquinoline is one of the most important simple nitrogen heterocycles, being widespread in nature and present in a broad variety of pharmacologically active compounds. This Review summarizes the progress achieved in the chemistry of tetrahydroquinolines, with emphasis on their synthesis, during the period from mid-2010 to early 2018.
Similar articles
-
Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants.Bioorg Med Chem Lett. 2009 Sep 1;19(17):5119-23. doi: 10.1016/j.bmcl.2009.07.031. Epub 2009 Jul 10. Bioorg Med Chem Lett. 2009. PMID: 19631528
-
Expanding the tetrahydroquinoline pharmacophore.Bioorg Med Chem Lett. 2017 Apr 15;27(8):1714-1720. doi: 10.1016/j.bmcl.2017.02.077. Epub 2017 Mar 6. Bioorg Med Chem Lett. 2017. PMID: 28318941
-
Quinolines and structurally related heterocycles as antimalarials.Eur J Med Chem. 2010 Aug;45(8):3245-64. doi: 10.1016/j.ejmech.2010.04.011. Epub 2010 Apr 18. Eur J Med Chem. 2010. PMID: 20466465 Review.
-
Synthesis and biological evaluation of some novel tetrahydroquinolines as anticancer and antimicrobial agents.J Enzyme Inhib Med Chem. 2014 Jun;29(3):367-78. doi: 10.3109/14756366.2013.787421. Epub 2013 Apr 22. J Enzyme Inhib Med Chem. 2014. PMID: 23607308
-
Styrylquinoline - A Versatile Scaffold in Medicinal Chemistry.Med Chem. 2020;16(2):141-154. doi: 10.2174/1573406415666190603103012. Med Chem. 2020. PMID: 31161997 Review.
Cited by
-
Borane-catalyzed cascade Friedel-Crafts alkylation/[1,5]-hydride transfer/Mannich cyclization to afford tetrahydroquinolines.Chem Sci. 2021 Dec 20;13(3):775-780. doi: 10.1039/d1sc05629h. eCollection 2022 Jan 19. Chem Sci. 2021. PMID: 35173942 Free PMC article.
-
Synthesis of dihydroisoindolo[2,1-a]quinolin-11-ones, their in silico ADMET properties and in vitro antitumor activities.RSC Adv. 2020 Nov 19;10(69):42287-42296. doi: 10.1039/d0ra04555a. eCollection 2020 Nov 17. RSC Adv. 2020. PMID: 35516784 Free PMC article.
-
Practical iridium-catalyzed direct α-arylation of N-heteroarenes with (hetero)arylboronic acids by H2O-mediated H2 evolution.Nat Commun. 2021 Jul 9;12(1):4206. doi: 10.1038/s41467-021-24468-z. Nat Commun. 2021. PMID: 34244498 Free PMC article.
-
Visible-Light-Driven Stereoselective Annulation of Alkyl Anilines and Dibenzoylethylenes via Electron Donor-Acceptor Complexes.J Org Chem. 2021 Jan 15;86(2):1901-1910. doi: 10.1021/acs.joc.0c02819. Epub 2021 Jan 4. J Org Chem. 2021. PMID: 33397115 Free PMC article.
-
Alkynoates as Versatile and Powerful Chemical Tools for the Rapid Assembly of Diverse Heterocycles under Transition-Metal Catalysis: Recent Developments and Challenges.Top Curr Chem (Cham). 2021 Jan 5;379(1):3. doi: 10.1007/s41061-020-00316-4. Top Curr Chem (Cham). 2021. PMID: 33398642 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources