Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019;15(11):2754-2768.
doi: 10.1080/21645515.2019.1603984. Epub 2019 May 17.

Systematic review of the rotavirus infection burden in the WHO-EMRO region

Selim Badur  1 , Serdar Öztürk  1 , Priya Pereira  2 , Mohammad AbdelGhany  3 , Mansour Khalaf  4 , Youness Lagoubi  5 , Onur Ozudogru  6 , Kashif Hanif  7 , Debasish Saha  8
Affiliations

Systematic review of the rotavirus infection burden in the WHO-EMRO region

Selim Badur et al. Hum Vaccin Immunother. 2019.

Abstract

Rotavirus gastroenteritis imposes a heavy burden on low- and middle-income countries. The World Health Organization defines the Eastern Mediterranean region (WHO-EMRO) as a diverse area in terms of socioeconomic status and health indicators. Rotavirus vaccination has been introduced, at least partially, in 19 out of the 22 EM countries; however, vaccine coverage remains low, and data on rotavirus disease burden is scarce.Available data on rotavirus prevalence, seasonality, vaccination status, and genotype evolution was systematically compiled following a literature review that identified 165 relevant WHO-EMRO epidemiology studies published between 1990 and 2017.Although the infectious agents responsible for acute gastroenteritis vary over time, rotavirus remained the leading cause of acute gastroenteritis in children, as seen in 76.3% of reviewed publications. Younger children (<2 years old) were at higher risk and thus increased vaccination coverage and surveillance systems are required to reduce the rotavirus gastroenteritis burden in WHO-EMRO countries.

Keywords: Eastern Mediterranean region; Rotavirus; burden; children; gastroenteritis; incidence.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
WHO-EMRO region countries (i.e. Afghanistan, Bahrain, Djibouti, Egypt, Iran (Islamic Republic of), Iraq, Jordan, Kuwait, Lebanon, Libya, Morocco, Occupied Palestine Territory, Oman, Pakistan, Qatar, Somalia, Sudan, Syrian Arab Republic, Tunisia, United Arab Emirates (UAE), and Yemen) included in the study. UAE: United Arab Emirates.
Figure 2.
Figure 2.
Literature search strategy (limited to articles published between 1990 and 2017 with abstracts in English or French) using the keywords “rotavirus” and “[country name]”.
Figure 3.
Figure 3.
Prevalence of RVGE among cases of AGE in individual studies per country. The overall incidence was reported for studies detailing prevalence over several years, except when the study was comparing pre- and post-vaccination periods. In this case, the latest value was retained, as more actual.
None
See this image and copyright information in PMC

References

    1. Widdowson MA, Steele D, Vojdani J, Wecker J, Parashar U.. Global rotavirus surveillance: determining the need and measuring the impact of rotavirus vaccines. J Infect Dis. 2009;200(Suppl 1):S1–8. doi: 10.1086/605061. - DOI - PubMed
    1. Parashar UD, Hummelman EG, Bresee JS, Miller MA, Glass RI. Global illness and deaths caused by rotavirus disease in children. Emerg Infect Dis. 2003;9:565–72. - PMC - PubMed
    1. Tate JE, Burton AH, Boschi-Pinto C, Steele AD, Duque J, Parashar UD, World Health Organization-Coordinated Global Rotavirus Surveillance Network . 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis. Lancet Infect Dis. 2012;12:136–41. doi: 10.1016/S1473-3099(11)70253-5. - DOI - PubMed
    1. Tate JE, Burton AH, Boschi-Pinto C, Parashar UD; World Health Organization-Coordinated Global Rotavirus Surveillance Network . Global, regional, and national estimates of rotavirus mortality in children <5 years of age, 2000-2013. Clin Infect Dis. 2016;62(Suppl 2):S96–S105. doi: 10.1093/cid/civ1013. - DOI - PMC - PubMed
    1. Rota Council Global introduction status. 2017. [accessed 2017 December5]. http://rotacouncil.org/vaccine-introduction/global-introduction-status/.

Publication types

MeSH terms

Substances