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. 2019 Aug 1;200(3):393-396.
doi: 10.1164/rccm.201903-0669LE.

Mycobacterium avium Complex Diversity within Lung Disease, as Revealed by Whole-Genome Sequencing

Darwin J Operario  1 , Suporn Pholwat  1 , Alex F Koeppel  1 , Alyson Prorock  1 , Yongde Bao  1 , Katia Sol-Church  1 , Michele Scheurenbrand  1 , Melinda Poulter  1 , Stephen Turner  1 , Hardik I Parikh  1 , Amy Mathers  1 , Eric R Houpt  1
Affiliations

Mycobacterium avium Complex Diversity within Lung Disease, as Revealed by Whole-Genome Sequencing

Darwin J Operario et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Microbial community profile of Mycobacterium avium complex isolates, as determined by taxonomic classification using Kracken/Bracken. Each of the 95 isolates is organized vertically and clustered on their Bray-Curtis dissimilarity into four major groups: a predominantly Mycobacterium avium (blue), Mycobacterium intracellulare (orange), Mycobacterium chimaera (green), and a mixed “other” cluster (black), as seen on the dendrogram to the left. Each isolate’s species composition is indicated by the colored horizontal stacked bar. Each of the individual 35 patients is indicated to the right, and their longitudinal isolates are linked by a line, with the first collected isolate denoted by a filled circle and subsequent samples denoted by open circles. Patients not receiving therapy are shown in blue, receiving therapy in green, and relapse patients in red. Patients whose isolates were all identical (single nucleotide variant < 100) are shown encircled. Rx = prescription.
See this image and copyright information in PMC

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