Sorting Out Fate Determination

Mostafa Bakhti¹, Aimée Bastidas-Ponce², Heiko Lickert³

Affiliations

¹ Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
² Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Technical University of Munich, Medical Faculty, Munich, Germany.
³ Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Technical University of Munich, Medical Faculty, Munich, Germany. Electronic address: heiko.lickert@helmholtz-muenchen.de.

PMID: 30965032
DOI: 10.1016/j.devcel.2019.03.020

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Sorting Out Fate Determination

Mostafa Bakhti et al. Dev Cell. 2019.

Free article

. 2019 Apr 8;49(1):1-3.

doi: 10.1016/j.devcel.2019.03.020.

Authors

Mostafa Bakhti¹, Aimée Bastidas-Ponce², Heiko Lickert³

Affiliations

¹ Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.
² Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Technical University of Munich, Medical Faculty, Munich, Germany.
³ Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Stem Cell Research, Helmholtz Zentrum München, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Technical University of Munich, Medical Faculty, Munich, Germany. Electronic address: heiko.lickert@helmholtz-muenchen.de.

PMID: 30965032
DOI: 10.1016/j.devcel.2019.03.020

Abstract

How organ morphogenesis specifies cell fate and whether organ progenitors are predetermined or specified via niche signals are critical developmental biology questions. In this issue of Developmental Cell, Nyeng et al. (2019) modulate cell-cell adhesion in the pancreas and provide evidence that progenitors are plastic and instructed by niche signals.

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p120ctn-Mediated Organ Patterning Precedes and Determines Pancreatic Progenitor Fate.
Nyeng P, Heilmann S, Löf-Öhlin ZM, Pettersson NF, Hermann FM, Reynolds AB, Semb H. Nyeng P, et al. Dev Cell. 2019 Apr 8;49(1):31-47.e9. doi: 10.1016/j.devcel.2019.02.005. Epub 2019 Mar 7. Dev Cell. 2019. PMID: 30853440

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Sorting Out Fate Determination

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Sorting Out Fate Determination

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