Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Apr 8;7(2):7.
doi: 10.3390/jdb7020007.

Mesothelium and Malignant Mesothelioma

Emilye Hiriart  1 , Raymond Deepe  2 , Andy Wessels  3
Affiliations
Review

Mesothelium and Malignant Mesothelioma

Emilye Hiriart et al. J Dev Biol. .

Abstract

The mesothelium is an epithelial structure derived from the embryonic mesoderm. It plays an important role in the development of a number of different organs, including the heart, lungs, and intestines. In this publication, we discuss aspects of the development of the mesothelium, where mesothelial structures can be found, and review molecular and cellular characteristics associated with the mesothelium. Furthermore, we discuss the involvement of the mesothelium in a number of disease conditions, in particular in the pathogenesis of mesotheliomas with an emphasis on malignant pleural mesothelioma (MPM)-a primary cancer developing in the pleural cavity.

Keywords: cancer; development; malignant; mesothelioma; mesothelium.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Neumann V., Loseke S., Nowak D., Herth F.J., Tannapfel A. Malignant pleural mesothelioma: Incidence, etiology, diagnosis, treatment, and occupational health. Dtsch Arztebl Int. 2013;110:319–326. - PMC - PubMed
    1. Robinson B.M. Malignant pleural mesothelioma: An epidemiological perspective. Ann. Cardiothorac Surg. 2012;1:491–496. - PMC - PubMed
    1. Boussios S., Moschetta M., Karathanasi A., Tsiouris A.K., Kanellos F.S., Tatsi K., Katsanos K.H., Christodoulou D.K. Malignant peritoneal mesothelioma: Clinical aspects, and therapeutic perspectives. Ann. Gastroenterol. 2018;31:659–669. doi: 10.20524/aog.2018.0305. - DOI - PMC - PubMed
    1. Brenner J., Sordillo P.P., Magill G.B., Golbey R.B. Malignant mesothelioma of the pleura: Review of 123 patients. Cancer. 1982;49:2431–2435. doi: 10.1002/1097-0142(19820601)49:11<2431::AID-CNCR2820491134>3.0.CO;2-W. - DOI - PubMed
    1. Winters N.I., Thomason R.T., Bader D.M. Identification of a novel developmental mechanism in the generation of mesothelia. Development. 2012;139:2926–2934. doi: 10.1242/dev.082396. - DOI - PMC - PubMed

LinkOut - more resources