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. 2019 Apr 8;24(7):1375.
doi: 10.3390/molecules24071375.

New Dammarane-type Saponins from Gynostemma pentaphyllum

Po-Yen Chen  1   2 , Chih-Chao Chang  3 , Hui-Chi Huang  4 , Li-Jie Zhang  5 , Chia-Ching Liaw  6 , Yu-Chi Lin  7 , Nham-Linh Nguyen  8   9 , Thanh-Hoa Vo  10   11 , Yung-Yi Cheng  12   13 , Susan L Morris-Natschke  14 , Kuo-Hsiung Lee  15   16 , Yao-Haur Kuo  17   18   19
Affiliations

New Dammarane-type Saponins from Gynostemma pentaphyllum

Po-Yen Chen et al. Molecules. .

Abstract

Six new dammarane-type saponins, gypenosides CP1-6 (16), along with 19 known compounds 7⁻25, were isolated and characterized from the aerial parts of Gynostemma pentaphyllum. Among these compounds, eight dammarane-type saponins, 2, 5, 6, 7, 11, 12, 13, and 15, exhibited the greatest antiproliferative effects against two human tumor cell lines (A549 and HepG2).

Keywords: Gynostemma pentaphyllum; Jiaogulan; dammarane-type saponins; gypenosides antiproliferative activity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structures of compounds 1–6 isolated from G. pentaphyllum.
Figure 2
Figure 2
Key COSY, HMBC, and NOESY correlations of 1.
Figure 3
Figure 3
Key COSY and HMBC correlations of 2 and 5.
See this image and copyright information in PMC

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