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. 2018 Feb 11;10(2):175.
doi: 10.3390/polym10020175.

Formulation of Carbopol®/Poly(2-ethyl-2-oxazoline)s Mucoadhesive Tablets for Buccal Delivery of Hydrocortisone

Leire Ruiz-Rubio  1 , María Luz Alonso  2 , Leyre Pérez-Álvarez  3 , Rosa Maria Alonso  4 , Jose Luis Vilas  5 , Vitaliy V Khutoryanskiy  6
Affiliations

Formulation of Carbopol®/Poly(2-ethyl-2-oxazoline)s Mucoadhesive Tablets for Buccal Delivery of Hydrocortisone

Leire Ruiz-Rubio et al. Polymers (Basel). .

Abstract

Poly(2-ethyl-2-oxazoline) has become an excellent alternative to the use of poly(ethylene glycol) in pharmaceutical formulations due to its valuable physicochemical and biological properties. This work presents a formulation of poorly-water soluble drug, hydrocortisone, using interpolymer complexes and physical blends of poly(2-ethyl-2-oxazoline)s and two Carbopols® (Carbopol 974 and Carbopol 971) for oromucosal administration. The swelling, hydrocortisone release and mucoadhesive properties of a series of tablet formulations obtained by combination of different Carbopols with poly(2-ethyl-2-oxazoline)s of different molecular weights have been evaluated in vitro.

Keywords: Carbopol®; interpolymer complexes; mucoadhesion; poly(2-ethyl-2-oxazoline).

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Yields of interpolymer complexes (wt %) for different Carbopol/poly(2-ethyl-2-oxazoline) systems in water and at pH 2.
Figure 2
Figure 2
Analysis of Carbopol 974/poly(2-ethyl-2-oxazoline) 500 complex, and pure components by: (a) FTIR; and (b) DSC.
Figure 3
Figure 3
The total work of adhesion (left) and detachment force (right) on porcine buccal tissues at 37 °C for: (a) Carbopol 974/poly(2-ethyl-2-oxazoline) tablets; and (b) Carbopol 971/poly(2-ethyl-oxazoline) tablets.
Figure 4
Figure 4
Swelling degree of pure polymers in simulated saliva.
Figure 5
Figure 5
Swelling degree and photographs of the tablets of Carbopols/Poly(2-ethyl-2-oxazoline)s in saliva at 37 °C at regular time intervals: (a) physical mixture; (b) interpolymer complexes formed in water; and (c) interpolymer complexes formed at pH 2 (A Carbopol 974; and B. Carbopol 971).
Figure 6
Figure 6
Release profiles of hydrocortisone from the tablets composed of poly(2-ethyl-2-oxazoline)s/Carbopols in simulated saliva at 37 °C: (a) physical mixture; (b) interpolymer complexes formed in water; and (c) interpolymer complexes formed at pH 2. (A Carbopol 974; and B. Carbopol 971).
See this image and copyright information in PMC

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