Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2019 Jul;32(4):186-194.
doi: 10.1177/0891988719841721. Epub 2019 Apr 9.

Inpatient Enhanced Multidisciplinary Care Effects on the Quality of Life for Parkinson Disease: A Quasi-Randomized Controlled Trial

Kohei Marumoto  1   2 , Kazumasa Yokoyama  1 , Tomomi Inoue  1 , Hiroshi Yamamoto  1 , Yuki Kawami  1 , Ayumi Nakatani  1 , Yoshihiro Fukazawa  1 , Yayoi Hosoe  1 , Aki Yamasaki  2 , Kazuhisa Domen  2
Affiliations
Randomized Controlled Trial

Inpatient Enhanced Multidisciplinary Care Effects on the Quality of Life for Parkinson Disease: A Quasi-Randomized Controlled Trial

Kohei Marumoto et al. J Geriatr Psychiatry Neurol. 2019 Jul.

Abstract

Objectives: To compare the effects of inpatient enhanced multidisciplinary care (EMC) and multidisciplinary rehabilitation (MR) on the symptoms and quality of life (QOL) of patients with Parkinson disease (PD) and to clarify the relation between reduction in symptoms and the improved QOL.

Methods: This study was a quasi-randomized controlled (alternate allocation), assessor-blinded, single-center study. We recruited 80 patients with idiopathic Parkinson disease, Hoehn and Yahr stage 2 to 4, on stable medication. Patients were included in an EMC or MR group. Both rehabilitation programs were performed for 8 weeks (17 h/wk). Main outcome measures were Parkinson's Disease Questionnaire-39 and Unified Parkinson's Disease Rating Scale.

Results: The EMC induced significant improvements in QOL compared to MR. We found that body axis symptoms (rising from a chair, posture, postural stability, falling, and walking) as well as nonmotor symptoms (depression) in patients with PD were relieved by the inpatient EMC.

Conclusions: Enhanced multidisciplinary care for patients with PD appears to be effective in improving the QOL. The improvement in motor and nonmotor symptoms, including depression, may contribute to the improved QOL.

Keywords: Parkinson disease; aerobic exercise; depression; multidisciplinary care; nursing; quality of life.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Study design. Patients were quasi-randomly assigned to an enhanced multidisciplinary care (EMC) or multidisciplinary rehabilitation (MR) group after passing the phone screening procedure. ANOVA indicates analysis of variance
Figure 2.
Figure 2.
Effects of enhanced multidisciplinary care (EMC). Results of analysis of variance (ANOVA) showed the time course of PDQ-39 was different between the EMC and multidisciplinary rehabilitation (MR) groups. Between-group comparisons showed that improvement scores of PDQ-39 were greater in the EMC than in the MR group posttreatment (P = .0019). N = 36/36, *P < .05. PDQ-39 indicates Parkinson’s Disease Questionnaire-39; UPDRS, Unified Parkinson’s Disease Rating Scale.
Figure 3.
Figure 3.
Analysis of improved symptom factors in relation to changes in quality of life (QOL). The reduction in depression (item 3) of UPDRS part1 correlated with the improved PDQ-39 total scores (r = .763, P < .0001). N =72. PDQ-39 indicates Parkinson’s Disease Questionnaire-39; UPDRS, Unified Parkinson’s Disease Rating Scale.
See this image and copyright information in PMC

References

    1. Lang AE, Lozano AM. Parkinson’s disease. First of two parts. N Engl J Med. 1998;339(15):1044–1053. - PubMed
    1. Pont-Sunyer C, Hotter A, Gaig C, et al. The onset of nonmotor symptoms in Parkinson’s disease (the ONSET PD study). Mov Disord. 2015;30(2):229–237. - PubMed
    1. Karlsen KH, Larsen J, Tandberg E, Maeland JG. Influence of clinical and demographic variables on quality of life in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1999;66(4):431–435. - PMC - PubMed
    1. Peto V, Jenkinson C, Fitzpatrick R, Greenhall R. The development and validation of a short measure of functioning and well being for individuals with Parkinson’s disease. Qual Life Res. 1995;4(3):241–248. - PubMed
    1. Schrag A, Jahanshahi M, Quinn N. What contributes to quality of life in patients with Parkinson’s disease? J Neurol Neurosurg Psychiatry. 2000;69(3):308–312. - PMC - PubMed

Publication types