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Case Reports
. 2019 Feb;23(Suppl 1):7-11.
doi: 10.4103/jomfp.JOMFP_100_17.

Evaluation of a case of diffuse large B-cell lymphoma

Ramandeep Singh Narang  1 , Adesh Singh Manchanda  1 , Harshveer Kaur  1
Affiliations
Case Reports

Evaluation of a case of diffuse large B-cell lymphoma

Ramandeep Singh Narang et al. J Oral Maxillofac Pathol. 2019 Feb.

Abstract

Lymphomas are a group of malignant blood cell tumors that develop from lymphocytes representing 2.2% of all malignant neoplasms of the head and neck. Two main categories of lymphomas are Hodgkin's lymphoma and non-Hodgkin's lymphoma (NHL) of which 90% are of the NHL type. Several classification systems have existed for lymphomas, the objectives of which are to help in identification of homogeneous group of well-defined entities and facilitating the recognition of uncommon diseases that require further classification as it affects prognosis and therapeutic implications. Diffuse large B-cell lymphoma (DLBCL) is the most common NHL in the oral cavity involving Waldeyer's ring, base of the tongue, buccal mucosa and hard palate. DLBCL can be divided into germinal center B-cell-like, activated B-cell-like or type 3 gene expression profiles. This paper highlights a case report of DLBCL revisiting the intricacies and difficulties involved in establishing a diagnosis.

Keywords: Activated B-cell like; diffuse large B-cell lymphoma; lymphoma.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
A proliferative growth in lower buccal vestibule and alveolus in relation to tooth #34, #35 and #36
Figure 2
Figure 2
Orthopantomography showing hazy radiolucencies in the alveolar process from #34 to #36 region with floating tooth appearance
Figure 3
Figure 3
Microscopic examination exhibited a diffuse monomorphic population of small round cells having vesicular nuclei and eosinophilic cytoplasm (H and E, ×40)
Figure 4
Figure 4
Immunohistochemistry shows immunoreactivity for CD20, BCL-6 and MUM1 and immunonegativity for CD10 and CD3. Ki67 proliferative index is 80%
See this image and copyright information in PMC

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