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. 2019 Nov;19(21-22):e1800447.
doi: 10.1002/pmic.201800447. Epub 2019 May 13.

Proteomics Approaches to Define Senescence Heterogeneity and Chemotherapy Response

Coralie Petit  1   2 , Jordan Guillon  1   2 , Bertrand Toutain  1   2 , Alice Boissard  1   2 , Anne Patsouris  1   2 , Eric Lelièvre  1   2 , Catherine Guette  1   2 , Olivier Coqueret  1   2
Affiliations

Proteomics Approaches to Define Senescence Heterogeneity and Chemotherapy Response

Coralie Petit et al. Proteomics. 2019 Nov.

Abstract

In primary cells, senescence induces a permanent proliferative arrest to prevent the propagation of malignant cells. However, the outcome of senescence is more complex in advanced cancer cells where senescent states are heterogeneous. Here, this heterogeneity is discussed and it is proposed that proteomic analysis should be used to identify specific signatures of cancer cells that use this pathway as an adaptive mechanism. Since senescent cells produce an inflammatory secretome, MRM approaches and quantification with internal standards might be particularly suited to follow the expression of the corresponding markers in body fluids. Used in combination with imaging medical technics, a better characterization of senescence heterogeneity should help to monitor the response to chemotherapy treatment.

Keywords: chemotherapy; secretome; senescence; tumor escape.

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References

    1. M. Serrano, A. W. Lin, M. E. McCurrach, D. Beach, S. W. Lowe, Cell 1997, 88, 593.
    1. P. A. Perez-Mancera, A. R. Young, M. Narita, Nat. Rev. Cancer 2014, 14, 547.
    1. C. Michaloglou, L. C. Vredeveld, M. S. Soengas, C. Denoyelle, T. Kuilman, C. M. van der Horst, D. M. Majoor, J. W. Shay, W. J. Mooi, D. S. Peeper, Nature 2005, 436, 720.
    1. R. H. te Poele, A. L. Okorokov, L. Jardine, J. Cummings, S. P. Joel, Cancer Res. 2002, 62, 1876.
    1. C. M. Beausejour, A. Krtolica, F. Galimi, M. Narita, S. W. Lowe, P. Yaswen, J. Campisi, EMBO J. 2003, 22, 4212.

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