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. 2020 Oct;34(19):2816-2821.
doi: 10.1080/14786419.2019.1596092. Epub 2019 Apr 10.

Bioactive triterpenoids from Sambucus javanica Blume

Feilong Chen  1 , Dong-Li Liu  1 , Wei Wang  1 , Xiao-Man Lv  1 , Weixi Li  1 , Li-Dong Shao  1 , Wen-Jing Wang  1
Affiliations

Bioactive triterpenoids from Sambucus javanica Blume

Feilong Chen et al. Nat Prod Res. 2020 Oct.

Abstract

A new triterpene, javablumine A (1) along with six known ones were isolated from the aerial parts of Sambucus javanica Blume. They were identified as 3β,23-dihydroxy-11α,12α-epoxy-urs-20(30)-en-28,13β-olide (1), ursolic acid (2), pomolic acid (3), oleanic acid (4), 2α-hydroxy-oleanolic acid (5), α-amyrin (6), and lupeol palmitate (7), respectively. Compounds 1 and 3 exhibited inhibitory effect against nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.7 macrophage cell lines with IC50 values of 17.4 and 26.2 μM, respectively.

Keywords: Sambucus javanica Blume.; javablumine A; triterpenes.

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