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Editorial
. 2019 Apr 25;380(17):1667-1668.
doi: 10.1056/NEJMe1904140. Epub 2019 Apr 10.

Can Immune Checkpoint Inhibitors Keep JC Virus in Check?

Igor J Koralnik  1
Affiliations
Editorial

Can Immune Checkpoint Inhibitors Keep JC Virus in Check?

Igor J Koralnik. N Engl J Med. .
No abstract available

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Comment on

  • Treatment of Progressive Multifocal Leukoencephalopathy with Nivolumab.
    Walter O, Treiner E, Bonneville F, Mengelle C, Vergez F, Lerebours F, Delobel P, Liblau R, Martin-Blondel G; Immune Checkpoint Inhibitors in PML Study Group. Walter O, et al. N Engl J Med. 2019 Apr 25;380(17):1674-1676. doi: 10.1056/NEJMc1816198. Epub 2019 Apr 10. N Engl J Med. 2019. PMID: 30969500 No abstract available.
  • Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy.
    Cortese I, Muranski P, Enose-Akahata Y, Ha SK, Smith B, Monaco M, Ryschkewitsch C, Major EO, Ohayon J, Schindler MK, Beck E, Reoma LB, Jacobson S, Reich DS, Nath A. Cortese I, et al. N Engl J Med. 2019 Apr 25;380(17):1597-1605. doi: 10.1056/NEJMoa1815039. Epub 2019 Apr 10. N Engl J Med. 2019. PMID: 30969503 Clinical Trial.
  • Treatment of Progressive Multifocal Leukoencephalopathy with Pembrolizumab.
    Rauer S, Marks R, Urbach H, Warnatz K, Nath A, Holland S, Weiller C, Grimbacher B. Rauer S, et al. N Engl J Med. 2019 Apr 25;380(17):1676-1677. doi: 10.1056/NEJMc1817193. Epub 2019 Apr 10. N Engl J Med. 2019. PMID: 30969507 No abstract available.

References

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    1. Rauer S, Marks R, Urbach H, et al. Treatment of progressive multifocal leukoencephalopathy with pembrolizumab. N Engl J Med 2019;380:1676–7. - PubMed
    1. Walter O, Treiner E, Bonneville F, et al. Treatment of progressive multifocal leukoencephalopathy with nivolumab. N Engl J Med 2019;380:1674–6. - PubMed
    1. Tan CS, Bord E, Broge TA Jr, et al. Increased program cell death-1 expression on T lymphocytes of patients with progressive multifocal leukoencephalopathy. J Acquir Immune Defic Syndr 2012;60:244–8. - PMC - PubMed
    1. Fessas P, Lee H, Ikemizu S, Janowitz T. A molecular and preclinical comparison of the PD-1-targeted T-cell checkpoint inhibitors nivolumab and pembrolizumab. Semin Oncol 2017; 44:136–40. - PMC - PubMed