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Book

Neurofibroma

Lynn Messersmith  1 , Kevin Krauland  1
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Free Books & Documents
Book

Neurofibroma

Lynn Messersmith et al.
Free Books & Documents

Excerpt

Neurofibromas are the most prevalent benign peripheral nerve sheath tumor. Often appearing as a soft, skin-colored papule or small subcutaneous nodule, they arise from endoneurium and the connective tissues of peripheral nerve sheaths. Neurofibromas are comprised of Schwann cells, fibroblasts, perineural cells, and mast cells in a variably myxoid background. A mutation in the NF1 gene causes neurofibromas. There are three main types of neurofibromas: localized (most common), diffuse, and plexiform. Although the majority of neurofibromas occur sporadically and have an extremely low risk of malignant transformation, the plexiform type is pathognomonic for neurofibromatosis type 1 (NF 1). It carries an increased risk of malignant transformation. The complete excision of the lesion is curative.

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Conflict of interest statement

Disclosure: Lynn Messersmith declares no relevant financial relationships with ineligible companies.

Disclosure: Kevin Krauland declares no relevant financial relationships with ineligible companies.

References

    1. Ferner RE, O'Doherty MJ. Neurofibroma and schwannoma. Curr Opin Neurol. 2002 Dec;15(6):679-84. - PubMed
    1. Lassmann H, Jurecka W, Lassmann G, Gebhart W, Matras H, Watzek G. Different types of benign nerve sheath tumors. Light microscopy, electron microscopy and autoradiography. Virchows Arch A Pathol Anat Histol. 1977 Sep 28;375(3):197-210. - PubMed
    1. Skovronsky DM, Oberholtzer JC. Pathologic classification of peripheral nerve tumors. Neurosurg Clin N Am. 2004 Apr;15(2):157-66. - PubMed
    1. Hernández-Martín A, Duat-Rodríguez A. An Update on Neurofibromatosis Type 1: Not Just Café-au-Lait Spots, Freckling, and Neurofibromas. An Update. Part I. Dermatological Clinical Criteria Diagnostic of the Disease. Actas Dermosifiliogr. 2016 Jul-Aug;107(6):454-64. - PubMed
    1. Ferner RE, Gutmann DH. Neurofibromatosis type 1 (NF1): diagnosis and management. Handb Clin Neurol. 2013;115:939-55. - PubMed

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