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Book

Metronidazole

Connor B. Weir  1 , Jacqueline K. Le  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Free Books & Documents
Book

Metronidazole

Connor B. Weir et al.
Free Books & Documents

Excerpt

Metronidazole is one of the mainstay drugs for the treatment of anaerobic bacterial infections, protozoal infections, and microaerophilic bacterial infections. It is cytotoxic to facultative anaerobic microorganisms. It is used to treat intestinal amebiases, liver amebiasis, bacterial septicemia, bone and joint infections, meningitis, brain abscess, endocarditis, endometritis, bacterial vaginosis, intra-abdominal infections, lower respiratory tract infections, skin structure infections, and surgical prophylaxis colorectal surgeries. This activity will highlight the mechanism of action, adverse event profile, contraindications, monitoring, and other key factors pertinent to interprofessional team members in the care of patients being treated with this medication.

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Conflict of interest statement

Disclosure: Connor Weir declares no relevant financial relationships with ineligible companies.

Disclosure: Jacqueline Le declares no relevant financial relationships with ineligible companies.

References

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    1. Löfmark S, Edlund C, Nord CE. Metronidazole is still the drug of choice for treatment of anaerobic infections. Clin Infect Dis. 2010 Jan 01;50 Suppl 1:S16-23. - PubMed
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    1. Nix DE, Tyrrell R, Müller M. Pharmacodynamics of metronidazole determined by a time-kill assay for Trichomonas vaginalis. Antimicrob Agents Chemother. 1995 Aug;39(8):1848-52. - PMC - PubMed
    1. Ralph ED, Kirby WM. Unique bactericidal action of metronidazole against Bacteroides fragilis and Clostridium perfringens. Antimicrob Agents Chemother. 1975 Oct;8(4):409-14. - PMC - PubMed

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