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Book

Leukocyte Adhesion Deficiency

Angel A. Justiz Vaillant  1 , Faran Ahmad  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Leukocyte Adhesion Deficiency

Angel A. Justiz Vaillant et al.
Free Books & Documents

Excerpt

Leukocyte adhesion deficiency (LAD) is a defect of cellular adhesion molecules resulting in clinical syndromes. It is a combined (B cell) and cellular (T cell) immunodeficiency disorder.

Major immunologic features:

  1. There is an inability to form pus.

  2. There is a deficiency of various glycoproteins, including LFA-1/Mac-1, glycoprotein 150/95.

  3. Leukocytes cannot migrate to infection sites to kill invading microorganisms due to mutations in the CD18 glycoprotein.

  4. Adhesion molecule deficiency results in an abnormal inflammatory response and eventually recurrent bacterial infections.

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Conflict of interest statement

Disclosure: Angel Justiz Vaillant declares no relevant financial relationships with ineligible companies.

Disclosure: Faran Ahmad declares no relevant financial relationships with ineligible companies.

References

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    1. Niethammer D, Dieterle U, Kleihauer E, Wildfeuer A, Haferkamp O, Hitzig WH. An inherited defect in granulocyte function: impaired chemotaxis, phagocytosis and intracellular killing of microorganisms. Helv Paediatr Acta. 1976 Apr;30(6):537-41. - PubMed
    1. Stepensky PY, Wolach B, Gavrieli R, Rousso S, Ben Ami T, Goldman V, Rozovsky K, Hanna S, Etzioni A, Weintraub M. Leukocyte adhesion deficiency type III: clinical features and treatment with stem cell transplantation. J Pediatr Hematol Oncol. 2015 May;37(4):264-8. - PubMed
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