Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Felbamate

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Felbamate

Preeti Patel et al.
Free Books & Documents

Excerpt

Felbamate is an anti-epileptic drug that the Food and Drug Administration approved for the management of focal seizures and Lennox-Gastaut syndrome. It should be a consideration for patients with drug-resistant epilepsy where the benefit of seizure control outweighs the risk of severe idiosyncratic reactions. This activity focuses on the indications, mechanism of action, methods of administration, significant adverse effects, and contraindications. Additionally, this CME reviews the monitoring and toxicity of felbamate. Understanding the complex pharmacology of felbamate enables healthcare professionals to tailor treatments for a patient-centered approach. This continuing medical education (CME) activity is designed to provide essential knowledge and practical tools for the optimal administration of felbamate. This educational initiative highlights the significant role of the interprofessional healthcare team in managing felbamate therapy. The CME program aims to provide evidence-based medicine to improve patient care and outcomes. It focuses on strategies to minimize adverse reactions while maximizing the effectiveness of lidocaine. This training will equip healthcare professionals with the knowledge to deliver safe, effective, and individualized care during felbamate administration.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Preeti Patel declares no relevant financial relationships with ineligible companies.

Disclosure: Robert Carson declares no relevant financial relationships with ineligible companies.

References

    1. Leitch B. Molecular Mechanisms Underlying the Generation of Absence Seizures: Identification of Potential Targets for Therapeutic Intervention. Int J Mol Sci. 2024 Sep 11;25(18) - PMC - PubMed
    1. Samanta D, Bhalla S, Bhatia S, Fine AL, Haridas B, Karakas C, Keator CG, Koh HY, Perry MS, Stafstrom CE, Vidaurre J, Warren AEL. Antiseizure medications for Lennox-Gastaut Syndrome: Comprehensive review and proposed consensus treatment algorithm. Epilepsy Behav. 2025 Mar;164:110261. - PubMed
    1. French J, Smith M, Faught E, Brown L. Practice advisory: The use of felbamate in the treatment of patients with intractable epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology. 1999 May 12;52(8):1540-5. - PubMed
    1. Zhu Z, Zhang Z, Xiao W, Wang C, Liang R. Efficacy and safety of pharmacological and non-pharmacological therapies in Lennox-Gastaut syndrome: a systematic review and network meta-analysis. Front Pharmacol. 2025;16:1522543. - PMC - PubMed
    1. Amrutkar CV, Lui F. StatPearls [Internet] StatPearls Publishing; Treasure Island (FL): 2025. Apr 20, Lennox-Gastaut Syndrome. - PubMed

Publication types

LinkOut - more resources