Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Apr 9;11(4):172.
doi: 10.3390/pharmaceutics11040172.

Age-Related Medicine

John Wahlich  1 , Mine Orlu  2 , Alpana Mair  3 , Sven Stegemann  4 , Diana van Riet-Nales  5
Affiliations

Age-Related Medicine

John Wahlich et al. Pharmaceutics. .

Abstract

A meeting organised by the Academy of Pharmaceutical Sciences focussed on the challenges of developing medicines for older adults. International experts discussed the complexity introduced by polypharmacy and multiple morbidities and how the risk⁻benefit ratio of a medicine changes as an individual ages. The way in which regulatory authorities are encouraging the development of age-appropriate medicines was highlighted. Examples were provided of the difficulties faced by the older population with some medicinal products and suggestions given as to how the pharmaceutical scientist can build the requirements of the older population into their development of new medicines, as well as improvements to existing ones.

Keywords: SIMPATHY; ageing; multiple morbidities; pharmaceutical sciences; polypharmacy; product development.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest. D.V.R.-N. is an expert of the European Medicines Agency (EMA) and a member of the EMA Quality Working Party.

References

    1. Dong X., Milholland B., Vijiq J. Evidence for a limit to human lifespan. Nature. 2016;538:257–259. doi: 10.1038/nature19793. - DOI - PMC - PubMed
    1. Free Dictionary. [(accessed on 31 March 2019)]; Available online: https://www.thefreedictionary.com/
    1. Wagner K.H., Cameron-Smith D., Wessner B., Franzke B. Biomarkers of Aging: From Function to Molecular Biology. Nutrients. 2016;8:338. doi: 10.3390/nu8060338. - DOI - PMC - PubMed
    1. Belsky D.W., Caspi A., Houts R., Cohen H.J., Corcoran D.L., Danese A., Israel S., Levine M.E., Suquden K., Williams B., et al. Quantification of biological aging in young adults. Proc. Natl. Acad Sci. USA. 2015;112:4104–4110. doi: 10.1073/pnas.1506264112. - DOI - PMC - PubMed
    1. Artaud F., Sabia S., Aline D., Kivimaki M., Singh-Manoux A., Elbaz A. Trajectories of Unhealthy Behaviors in Midlife and Risk of Disability at Older Ages in the Whitehall II Cohort Study. J. Gerontol. A Biol. Sci. Med. Sci. 2016;71:1500–1506. doi: 10.1093/gerona/glw060. - DOI - PMC - PubMed

Publication types

LinkOut - more resources