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Comparative Study
. 2019 Oct;51(4):1557-1567.
doi: 10.4143/crt.2018.681. Epub 2019 Apr 1.

Characteristics, Prognostic Factors, and Survival of Patients with NK/T-Cell Lymphoma of Non-upper Aerodigestive Tract: A 17-Year Single-Center Experience

Ze-Long Liu  1 , Xi-Wen Bi  1 , Xue-Wen Zhang  1 , De-Xin Lei  1 , Pan-Pan Liu  1 , Hang Yang  1 , Yan Gao  1 , Yuan-Xue Jiang  2 , Wen-Qi Jiang  1 , Yi Xia  1
Affiliations
Comparative Study

Characteristics, Prognostic Factors, and Survival of Patients with NK/T-Cell Lymphoma of Non-upper Aerodigestive Tract: A 17-Year Single-Center Experience

Ze-Long Liu et al. Cancer Res Treat. 2019 Oct.

Abstract

Purpose: The extranodal natural killer (NK)/T-cell lymphoma (NKTCL) of non-upper aerodigestive tract (NUAT) was found to have clinical heterogeneity compared with NKTCL of the upper aerodigestive tract (UAT) in small scale studies. We conducted this study in a much larger cohort to analyze the clinical characteristics, prognostic factors, treatment modality, and clinical outcomes of patients with NUAT-NKTCL.

Materials and methods: From January 2001 to December 2017, a total of 757 NKTCL patients were identified and included in this study, including 92 NUAT-NKTCL patients (12.2%) and 665 UAT-NKTCL patients (87.8%).

Results: NUAT-NKTCL patients had relatively poorer performance status, more unfavorable prognostic factors, and more advanced stage, compared with UAT-NKTCL patients. The 5-year overall survival (OS) was 34.7% for NUAT-NKTCL, which was significantly worse than UAT-NKTCL (64.2%, p<0.001). The median OS duration was 30.9 months for NUAT-NKTCL. Multivariate analysis showed that presence with B symptoms and elevated serum lactate dehydrogenase independently predicted worse OS. International prognostic index score and prognostic index of natural killer lymphoma score still had prognostic values in NUAT-NKTCL, while the Ann Arbor system could not accurately predict the OS.

Conclusion: NUAT-NKTCL is a distinctive subtype of NKTCL in many aspects. Patients with NUAT-NKTCL have relatively poorer performance status, more unfavorable prognostic factors, more advanced stage, and poorer prognosis.

Keywords: Extranodal NK-T-Cell Lymphoma; Non-upper aerodigestive tract; Prognostic factors; Survival.

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Conflict of interest statement

Conflict of interest relevant to this article was not reported.

Figures

Fig. 1.
Fig. 1.
Kaplan-Meier plots of overall survival (OS) (A) and progression-free survival (PFS) (B) for non-upper aerodigestive tract (NUAT)‒natural killer/T-cell lymphoma (NKTCL) and upper aerodigestive tract (UAT)-NKTCL. HR, hazard ratio; CI, confidence interval.
Fig. 2.
Fig. 2.
Kaplan-Meier plots of overall survivals (OS) for non-upper aerodigestive tract–natural killer/T-cell lymphoma by the International Prognostic Index (IPI) score (A) and the Prognostic Index of Natural Killer Lymphoma (PINK) score (B). HR, hazard ratio; CI, confidence interval.
Fig. 3.
Fig. 3.
Kaplan-Meier plots of overall survival (OS) (A) and progression-free survival (PFS) (B) for non-upper aerodigestive tract–natural killer/T-cell lymphoma (NKTCL) by Ann Arbor stage; and Kaplan-Meier plots of OS (C) and PFS (D) for upper aerodigestive tract–NKTCL by Ann Arbor stage. HR, hazard ratio; CI, confidence interval.
See this image and copyright information in PMC

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