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Comparative Study
. 1986;66(3-4):271-80.
doi: 10.1007/BF01260919.

Possible melatonin involvement in the hypotensive effect of MAO inhibitors

G F Oxenkrug, R B McCauley, D J Fontana, I M McIntyre, R L Commissaris
Comparative Study

Possible melatonin involvement in the hypotensive effect of MAO inhibitors

G F Oxenkrug et al. J Neural Transm. 1986.

Abstract

Effect of selective inhibitors of MAO-A and B isoenzymes on pineal melatonin (and related indoles), arterial blood pressure and brain MAO-A and B activities has been evaluated in intact, pinealectomized and sham-operated rats. Selective inhibition of MAO-A but not MAO-B activity stimulated pineal melatonin synthesis and decreased arterial blood pressure in intact and sham-operated animals. Pinealectomy attenuated the hypotensive effect of MAO-A inhibition. The possible melatonin contribution to both antidepressive and hypotensive effects of MAO inhibitors is discussed.

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