Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1986;66(3-4):271-80.
doi: 10.1007/BF01260919.

Possible melatonin involvement in the hypotensive effect of MAO inhibitors

G F Oxenkrug, R B McCauley, D J Fontana, I M McIntyre, R L Commissaris
Comparative Study

Possible melatonin involvement in the hypotensive effect of MAO inhibitors

G F Oxenkrug et al. J Neural Transm. 1986.

Abstract

Effect of selective inhibitors of MAO-A and B isoenzymes on pineal melatonin (and related indoles), arterial blood pressure and brain MAO-A and B activities has been evaluated in intact, pinealectomized and sham-operated rats. Selective inhibition of MAO-A but not MAO-B activity stimulated pineal melatonin synthesis and decreased arterial blood pressure in intact and sham-operated animals. Pinealectomy attenuated the hypotensive effect of MAO-A inhibition. The possible melatonin contribution to both antidepressive and hypotensive effects of MAO inhibitors is discussed.

PubMed Disclaimer

References

    1. Br J Pharmacol. 1976 Mar;56(3):360P-361P - PubMed
    1. Experientia. 1975 Jan 15;31(1):95-6 - PubMed
    1. Ann Med Exp Biol Fenn. 1973 Mar;51(3):93-103 - PubMed
    1. Lancet. 1964 Mar 7;1(7332):527-9 - PubMed
    1. Pharmacol Biochem Behav. 1983 Nov;19(5):891-4 - PubMed

Publication types

LinkOut - more resources