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. 2019 Aug;110(2):255-259.
doi: 10.1007/s12185-019-02638-6. Epub 2019 Apr 10.

Glucocorticoids promote response to thrombopoietin-receptor agonists in refractory ITP: a case series

Jacqueline N Poston  1   2   3   4 , Terry B Gernsheimer  5   6
Affiliations

Glucocorticoids promote response to thrombopoietin-receptor agonists in refractory ITP: a case series

Jacqueline N Poston et al. Int J Hematol. 2019 Aug.

Abstract

A proportion of patients with immune thrombocytopenic purpura are refractory to multiple therapies including thrombopoietin-receptor agonists (TPO-RA). We report 10 patients who did not respond to a TPO-RA until the addition of a glucocorticoid. These patients were previously treated with a median of 6 therapies. One patient elected to discontinue both medications despite persistent thrombocytopenia. The remaining 9 patients continued on the combination of prednisone (doses 5 mg every other day to 10 mg daily) and a TPO-RA. Combination therapy with low dose glucocorticoid and a TPO-RA may be an option for patients unresponsive to a TPO-RA alone.

Keywords: Autoimmune thrombocytopenia; Glucocorticoids; Immune thrombocytopenic purpura; Refractory; Thrombopoietin-receptor agonists.

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