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Editorial
. 2019 Apr 12;124(8):1151-1153.
doi: 10.1161/CIRCRESAHA.119.314877.

Sarcomere-Directed Calcium Reporters in Cardiomyocytes

Affiliations
Editorial

Sarcomere-Directed Calcium Reporters in Cardiomyocytes

Stuart G Campbell et al. Circ Res. .
No abstract available

Keywords: Editorials; calcium signaling; hypertrophic cardiomyopathy; sarcomeres; troponin.

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Figures

Figure 1:
Figure 1:
Possible explanations for increased myofilament Ca2+ transients in the presence of elevated myofilament-based Ca2+ buffering. (A) A naïve representation of the acute effects of enhanced Ca2+ buffering by TnC. (B) The steady-state consequences of enhanced myofilament Ca2+ buffering assuming that SERCA uptake exceeds extrusion by NCX. (C) The reverse scenario, in which NCX flux exceeds that of SERCA. (D) Localization of SERCA throughout the SR, including network and junctional SR, may provide a spatial advantage over NCX in terms of collecting excess Ca2+ buffered by myofilaments containing HCM-related mutations (diagram adapted from ref. 9).

Comment on

References

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