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Review
. 2019 Apr 12;124(8):1160-1162.
doi: 10.1161/CIRCRESAHA.118.314665.

Diabetic Cardiomyopathy

Wolfgang H Dillmann  1
Affiliations
Review

Diabetic Cardiomyopathy

Wolfgang H Dillmann. Circ Res. .

Abstract

Diabetic cardiomyopathy was initially described as a human pathophysiological condition in which heart failure occurred in the absence of coronary artery disease, hypertension, and valvular heart disease. Recent studies in diabetic animal models identify decreased cardiomyocyte function as an important mediating mechanism for heart failure. Decreased cardiomyocyte function is in part mediated by abnormal mitochondrial calcium handling and a decreased level of free matrix calcium levels which could be a good target for new therapeutic interventions.

Keywords: calcium; coronary artery disease; diabetes mellitus; diabetic cardiomyopathy; heart failure; mitochondria.

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References

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