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doi: 10.1016/j.chom.2019.03.015.
Can the Microbiome Deliver? A Proof-of-Concept Engineered E. coli PKU Therapeutic
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- PMID: 30974078
- DOI: 10.1016/j.chom.2019.03.015
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Can the Microbiome Deliver? A Proof-of-Concept Engineered E. coli PKU Therapeutic
Cell Host Microbe.
.
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Abstract
Phenylketonuria (PKU) is a rare genetic disorder that causes phenylalanine toxicity in the brain. Two studies, Crook et al. (2019), in this issue of Cell Host & Microbe, and Isabella et al. (2018), employ synthetic biology to develop a live bacterial therapeutic to treat PKU and potentially other metabolic diseases.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
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Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria.Nat Biotechnol. 2018 Oct;36(9):857-864. doi: 10.1038/nbt.4222. Epub 2018 Aug 13. Nat Biotechnol. 2018. PMID: 30102294
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Adaptive Strategies of the Candidate Probiotic E. coli Nissle in the Mammalian Gut.Cell Host Microbe. 2019 Apr 10;25(4):499-512.e8. doi: 10.1016/j.chom.2019.02.005. Epub 2019 Mar 26. Cell Host Microbe. 2019. PMID: 30926240 Free PMC article.
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