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Comment
. 2019 Apr 10;25(4):482-483.
doi: 10.1016/j.chom.2019.03.010.

Complement Seals a Virus to Block Infection

Jason G Smith  1 , Glen R Nemerow  2
Affiliations
Free article
Comment

Complement Seals a Virus to Block Infection

Jason G Smith et al. Cell Host Microbe. .
Free article

Abstract

In this issue of Cell Host & Microbe, Bottermann et al. (2019) reveal that complement component C4 inhibits adenovirus by inactivating the virus capsid through mechanisms requiring antibody engagement, but not late-acting complement pathways. This antiviral function likely broadly impacts non-enveloped viruses and may help illuminate the process of virus disassembly.

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  • Complement C4 Prevents Viral Infection through Capsid Inactivation.
    Bottermann M, Foss S, Caddy SL, Clift D, van Tienen LM, Vaysburd M, Cruickshank J, O'Connell K, Clark J, Mayes K, Higginson K, Lode HE, McAdam MB, Sandlie I, Andersen JT, James LC. Bottermann M, et al. Cell Host Microbe. 2019 Apr 10;25(4):617-629.e7. doi: 10.1016/j.chom.2019.02.016. Epub 2019 Mar 26. Cell Host Microbe. 2019. PMID: 30926239 Free PMC article.

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