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. 2019 Apr 10;11(4):339.
doi: 10.3390/v11040339.

Histo-Blood Group Antigens in Children with Symptomatic Rotavirus Infection

Raúl Pérez-Ortín  1 , Susana Vila-Vicent  2 , Noelia Carmona-Vicente  3 , Cristina Santiso-Bellón  4 , Jesús Rodríguez-Díaz  5 , Javier Buesa  6
Affiliations

Histo-Blood Group Antigens in Children with Symptomatic Rotavirus Infection

Raúl Pérez-Ortín et al. Viruses. .

Abstract

Group A rotaviruses are a major cause of acute gastroenteritis in children. The diversity and unequal geographical prevalence of rotavirus genotypes have been linked to histo-blood group antigens (HBGAs) in different human populations. In order to evaluate the role of HBGAs in rotavirus infections in our population, secretor status (FUT2+), ABO blood group, and Lewis antigens were determined in children attended for rotavirus gastroenteritis in Valencia, Spain. During three consecutive years (2013-2015), stool and saliva samples were collected from 133 children with rotavirus infection. Infecting viral genotypes and HBGAs were determined in patients and compared to a control group and data from blood donors. Rotavirus G9P[8] was the most prevalent strain (49.6%), followed by G1P[8] (20.3%) and G12P[8] (14.3%). Rotavirus infected predominantly secretor (99%) and Lewis b positive (91.7%) children. Children with blood group A and AB were significantly more prone to rotavirus gastroenteritis than those with blood group O. Our results confirm that a HBGA genetic background is linked to rotavirus P[8] susceptibility. Rotavirus P[8] symptomatic infection is manifestly more frequent in secretor-positive (FUT2+) than in non-secretor individuals, although no differences between rotavirus G genotypes were found.

Keywords: ABO group antigens; Lewis; gastroenteritis; histo-blood group antigens (HBGAs); rotavirus; secretor; susceptibility.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Temporal distribution of rotavirus G genotypes during the three-year study period. Regarding P genotypes, 98% of the strains were P[8] genotype with an overall dominance of G9P[8]. Abbreviations: ND, not determined.
See this image and copyright information in PMC

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