Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1986 Dec;83(23):8849-53.
doi: 10.1073/pnas.83.23.8849.

A GTP-binding protein of Escherichia coli has homology to yeast RAS proteins

J Ahnn, P E March, H E Takiff, M Inouye
Comparative Study

A GTP-binding protein of Escherichia coli has homology to yeast RAS proteins

J Ahnn et al. Proc Natl Acad Sci U S A. 1986 Dec.

Abstract

The DNA sequence of a gene (era) located immediately downstream of the gene (rnc) encoding ribonuclease III of Escherichia coli was determined and found to encode a protein of 316 amino acid residues. The amino acid sequence of this protein, Era, has significant similarity to the yeast RAS proteins. Overexpression of the Era protein was achieved and GTP cross-linking experiments demonstrated that the protein was indeed capable of binding GTP, as are the yeast and mammalian ras gene products. These data indicate that ras-related sequences occur not only in eukaryotes but also in prokaryotes.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1342-6 - PubMed
    1. Nature. 1983 Mar 3;302(5903):33-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Feb;74(2):560-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5463-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Apr;80(8):2112-6 - PubMed

Publication types

MeSH terms

Associated data