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Editorial
. 2019 Feb;9(2):127-133.
doi: 10.21037/qims.2019.01.07.

Living tissue intravoxel incoherent motion (IVIM) diffusion MR analysis without b=0 image: an example for liver fibrosis evaluation

Yì Xiáng J Wáng  1
Affiliations
Editorial

Living tissue intravoxel incoherent motion (IVIM) diffusion MR analysis without b=0 image: an example for liver fibrosis evaluation

Yì Xiáng J Wáng. Quant Imaging Med Surg. 2019 Feb.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The author has no conflicts of interest to declare.

Figures

Figure 1
Figure 1
1.5 T liver IVIM diffusion images with b-value =0, 1, 2, 15 s/mm2. The signal difference between b=0 s/mm2 image and b=1 or 2 s/mm2 images is dramatic, particularly the vessels show high signal without diffusion gradient while showing dark signal when the diffusion gradient is on even at b=1 s/mm2. [Reproduced with permission from (11)]. IVIM, intravoxel incoherent motion.
Figure 2
Figure 2
Two 1.5 T liver IVIM signal vs. b-value curves from b=0 to b=100 s/mm2. Note there is a sharp decrease of signal between b=0 vs. b=1, while the decrease of signal between b=1 vs. b=2 is much smaller. Thus the curves do not follow bi-exponential decay pattern. The ROI on liver parenchyma was drawn to avoid signal contamination from large vessels well; however, inevitably some very small vessels would have been included in the ROI. IVIM, intravoxel incoherent motion; ROI, region of interest.
Figure 3
Figure 3
Two 3T liver IVIM signal vs. b-value curves from b=0 to b=800 s/mm2. Note there is a sharp decrease of signal between b=0 vs. b=3, while the decrease of signal between b=3 vs. b=10 is much smaller. The signal decay curves between b=3 and b=800 are more likely to follow bi-exponential decay pattern. The ROI on liver parenchyma was drawn to avoid signal contamination from large vessels well; however, inevitably some very small vessels would have been included in the ROI. IVIM, intravoxel incoherent motion; ROI, region of interest.
Figure 4
Figure 4
Preliminary results of the initially analyzed subjects from our third study. B-values distribution: 0, 2, 5, 10, 15, 20, 25, 30, 40, 60, 80, 100, 150, 200, 400, 600 s/mm2, and threshold b-value is 60 s/mm2, 3T scanner. (A) Four healthy volunteers and three liver fibrosis patients cannot be separated by Dslow when b=0 image was included for bi-exponential IVIM analysis; while the volunteers and three liver fibrosis patients can be separated by Dslow when b=0 image was not included for bi-exponential decay IVIM analysis; (B) the same study subjects as in (A), healthy volunteers and liver fibrosis patients cannot be separated by PF when b=0 image was included for analysis; while volunteers and three liver fibrosis patients can be separated by PF when b=0 image was not included for analysis; (C) for without b=0 image analysis, seven healthy volunteers (green dots) and six liver fibrosis patients (red dots) can be separated by 3D display of three IVIM parameters (PF, Dfast, Dslow). IVIM, intravoxel incoherent motion; PF, perfusion fraction.
Figure 5
Figure 5
Study-2 results. 3D display of healthy volunteer group (green dots, n=26), patients without liver fibrosis (yellow dots, n=4), liver fibrosis stage 1–2 patient group (pink dots, n=7), and liver fibrosis stage 3–4 patient group (red dots, n=5). The volunteer group and liver fibrosis patient group can be separated by a defined plane. Note the distribution of patients without liver fibrosis (yellow dots) resembles healthy volunteers. [Reproduced with permission from (11)].
Figure 6
Figure 6
A single-slice single-breathhold (14 seconds) liver 12 b-values IVIM diffusion imaging obtained at a 3 Tesla MRI scanner equipped with dual transmitter (Achieva TX, Philips Healthcare, Best, The Netherlands). IVIM, intravoxel incoherent motion; MRI, magnetic resonance imaging.
See this image and copyright information in PMC

References

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