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. 2019 Mar 27:6:122-127.
doi: 10.1016/j.ejro.2019.03.002. eCollection 2019.

Diagnostic performance of 2015 American Thyroid Association guidelines and inter-observer variability in assigning risk category

Zhiyu Pang  1 , Myles Margolis  1 , Ravi J Menezes  1 , Hassaan Maan  1 , Sangeet Ghai  1
Affiliations

Diagnostic performance of 2015 American Thyroid Association guidelines and inter-observer variability in assigning risk category

Zhiyu Pang et al. Eur J Radiol Open. .

Erratum in

Abstract

Objective: To determine the interobserver variability of the 2015 American Thyroid Association (ATA) thyroid guidelines and to evaluate the diagnostic accuracy of the guidelines in detecting thyroid cancer.

Materials and methods: Sonographic patterns of 189 thyroid lesions were retrospectively analyzed by two radiologists according to the 2015 guidelines. The risk of malignancy was calculated for each pattern and compared with the published expected risk of malignancy.

Results: The observed risk of malignancy for very low suspicion, low suspicion, intermediate suspicion and high suspicion patterns were 2%, 12.7%, 26.3% and 29.8% respectively. Interobserver agreement for final category assignment was moderate (κ 0.518).

Conclusion: The estimated risk of malignancy in the high suspicion pattern of the 2015 ATA thyroid biopsy guidelines appears to be less than stated. However, this needs further validation in a larger cohort study.

Keywords: ATA guidelines; Fine needle aspiration biopsy; Interobserver agreement; Interobserver variability; Thyroid ultrasound.

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Figures

Fig. 1
Fig. 1
Sonographic patterns of 4, 4b, 5 and 5x in the study a. Sonographic pattern of Intermediate Suspicion (4): Hypoechoic solid nodule with smooth margins without microcalcifications, extrathyroidal extension, or taller than wide shape. 40-year-old female with papillary thyroid carcinoma. b. Sonographic pattern 4b: Hypoechoic and isoechoic areas to adjacent thyroid parenchyma, solid nodule with smooth margins without microcalcifications, extrathyroidal extension, or taller than wide shape. 48-year-old female with benign thyroid nodule. c. Sonographic pattern of high suspicion (5): solid hypoechoic nodule with microcalcifications. 40-year-old female with papillary thyroid carcinoma. d. Sonographic pattern of 5x: isoechoic nodule with taller-than-wide shape. 36-year-old female with benign thyroid nodule.
See this image and copyright information in PMC

References

    1. Dean D.S., Gharib H. Epidemiology of thyroid nodules. Best Pract. Res. Clin. Endocrinol. Metab. 2008;22(December 6):901–911. - PubMed
    1. Cho B.Y. Changes in the clinicopathological characteristics and outcomes of thyroid cancer in Korea over the past four decades. Thyroid. 2013;23(July 7):797–804. - PMC - PubMed
    1. Bibbins-Domingo K. Screening for thyroid Cancer: us preventive services task force recommendation statement. JAMA. 2017;317(May 18):1882–1887. - PubMed
    1. Brito J.P., Davies L. Is there really an increased incidence of thyroid cancer? Curr. Opin. Endocrinol. Diabetes Obes. 2014;21(October 5):405–408. - PubMed
    1. Brito J.P., Al Nofal A., Montori V.M., Hay I.D., Morris J.C. The impact of subclinical disease and mechanism of detection on the rise in thyroid Cancer incidence: a population-based study in Olmsted County, Minnesota during 1935 through 2012. Thyroid. 2015;25(September 9):999–1007. - PMC - PubMed