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Review
. 2019 Aug;208(3-4):295-303.
doi: 10.1007/s00430-019-00603-y. Epub 2019 Apr 11.

Impact of cytomegalovirus load on host response to sepsis

Thomas Marandu  1   2 , Michael Dombek  1 , Charles H Cook  3
Affiliations
Review

Impact of cytomegalovirus load on host response to sepsis

Thomas Marandu et al. Med Microbiol Immunol. 2019 Aug.

Abstract

There is a decades old association between cytomegalovirus reactivation and sepsis in immune-competent hosts. Much has been learned about this relationship, which has been described as bidirectional, meaning that the virus incites and is incited by the host's inflammatory response. More recent work has suggested that chronic viral infection leaves the host with exaggerated immunity to bacterial infections. In this review, the relationship between CMV and host responses to sepsis are reviewed, with particular attention to the impact that tissue viral load contributes to this phenomenon.

Keywords: Cytomegalovirus reactivation; Sepsis; Viral load.

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