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Randomized Controlled Trial
. 2019 Apr 11;11(4):820.
doi: 10.3390/nu11040820.

Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial

Yen-Wenn Liu  1   2 , Min Tze Liong  3 , Yu-Chu Ella Chung  4 , Hui-Yi Huang  5 , Wu-Shun Peng  6 , Yun-Fang Cheng  7 , Yu-Siou Lin  8 , Yu-Yu Wu  9 , Ying-Chieh Tsai  10   11
Affiliations
Randomized Controlled Trial

Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial

Yen-Wenn Liu et al. Nutrients. .

Abstract

This four-week, randomized, double-blind, placebo-controlled study investigated the effects of Lactobacillus plantarum PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7-15 in Taiwan. All subjects fulfilled the criteria for ASD diagnosis of DSM-V and the Autism Diagnostic Interview-Revised (ADI-R). Questionnaires used for the primary outcome measure include the Autism Behavior Checklist-Taiwan version (ABC-T), the Social Responsiveness Scale (SRS) and the Child Behavior Checklist (CBCL). The Swanson, Nolan, and Pelham-IV-Taiwan version (SNAP-IV) and the Clinical Global Impression-improvement (CGI-I) were used for the secondary outcome measure. The results showed that PS128 ameliorated opposition/defiance behaviors, and that the total score of SNAP-IV for younger children (aged 712) improved significantly compared with the placebo group. Additionally, several elements were also notably improved in the PS128 group after 28-day consumption of PS128. Further studies are needed to better clarify the effects of PS128 for younger children with ASD on broader symptoms.

Keywords: Lactobacillus plantarum PS128; anxiety; autism spectrum disorder (ASD); hyperactivity; psychobiotic.

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Conflict of interest statement

Y.-C.T. owns stock in Bened Biomedical Co., Ltd. Other authors declare no conflict of interest.

Figures

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Figure 1
Trial profile.
See this image and copyright information in PMC

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