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Review
. 2016 Mar 24;8(4):91.
doi: 10.3390/polym8040091.

Drug Delivery Systems Obtained from Silica Based Organic-Inorganic Hybrids

João Augusto Oshiro Junior  1 , Marina Paiva Abuçafy  2 , Eloísa Berbel Manaia  3 , Bruna Lallo da Silva  4 , Bruna Galdorfini Chiari-Andréo  5   6 , Leila Aparecida Chiavacci  7
Affiliations
Review

Drug Delivery Systems Obtained from Silica Based Organic-Inorganic Hybrids

João Augusto Oshiro Junior et al. Polymers (Basel). .

Abstract

This is a review of hybrid materials based on silica as an inorganic phase used as drug delivery systems (DDS). Silica based DDS have shown effectivity when compared with traditional delivery systems. They present advantages such as: (a) ability to maintain the therapeutic range with minor variations; (b) prevention of local and systemic toxic effects; (c) plasma concentrations increase of substances with a short half-life; and (d) reduction of the number of daily doses, which may increase patient adherence to the treatment. These advantages occur due to the physical, chemical and optical properties of these materials. Therefore, we discuss the properties and characteristics of them and we present some applications, using different approaches of DDS to ensure therapeutic effectiveness and side effects reduction such as implantable biomaterial, film-forming materials, stimuli-responsive systems and others.

Keywords: drug delivery systems; organic-inorganic materials; sol-gel process.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Representation of (A) Class I; (B) Class II; and (C) Class III of organic-inorganic hybrid materials. The white symbols represent the inorganic phase and the black ones represent the organic phase (adapted from the study by Benvenutti et al., 2009 [33]).
Figure 2
Figure 2
Number of publications which contains the terms “organic-inorganic” and “drug delivery” (ISI: Web of Science, accessed on 28 August 2015 [50]).
Figure 3
Figure 3
Schema of stimuli-responsive organic-inorganic materials for drug delivery systems (adapted from the study by Santilli et al., 2009 [60]).
Figure 4
Figure 4
Bone defect repair using biomaterials: (a) the biomaterial releases bioactive molecules that interact with the bone cells; (b) it increases the quantity of bone tissue and occurs the degradation of the biomaterial, and finally; (c) occurs the regeneration of the tissue without presence of biomaterial.
Figure 5
Figure 5
Molecules and biological interactions of ureasil-PEO and ureasil-PPO hybrid materials. Possible sites of bonding with the biological substrate and drugs are highlighted in the blue circles [64].
Figure 6
Figure 6
Possible links between sites of hybrid material and molecules (I, II and III) [60].
See this image and copyright information in PMC

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