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Review
. 2019 Jun;38(6):1691-1697.
doi: 10.1007/s10067-019-04548-8. Epub 2019 Apr 13.

Exceptional association of hypocomplementemic urticarial vasculitis syndrome (HUVS) and symptomatic pulmonary histoplasmosis: a case-based literature review

Mohammad Alomari  1 , Laith Al Momani  2 , Shrouq Khazaaleh  3 , Shaden Almomani  4 , Kinanah Yaseen  5 , Bassam Alhaddad  6
Affiliations
Review

Exceptional association of hypocomplementemic urticarial vasculitis syndrome (HUVS) and symptomatic pulmonary histoplasmosis: a case-based literature review

Mohammad Alomari et al. Clin Rheumatol. 2019 Jun.

Abstract

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare type III hypersensitivity disorder characterized by urticarial vasculitis and prolonged hypocomplementemia. Individuals with HUVS may also have joint involvement, pulmonary manifestations, ocular disease, kidney inflammation, or any other form of organ involvement. Hypocomplementemia, the presence of C1q antibody in the serum, and urticarial vasculitis are the keys to the diagnosis of HUVS. It has been reported to accompany certain infections such as hepatitis B, hepatitis C, infectious mononucleosis, and coxsackie group A. However, it has never been reported to be linked to histoplasmosis in the literature. To the best of our knowledge, we report the first case of HUVS presenting concurrently with pulmonary histoplasmosis.

Keywords: Histoplasmosis; Hypocomplementemia; Pulmonary; Urticaria; Vasculitis.

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